Signaling Transduction Network Mediated by Tumor Suppressor/Susceptibility Genes in NPC.

Current Genomics
Minghua WuGuiyuan Li

Abstract

Nasopharyngeal carcinoma (NPC) is a polygenetic disease. SPLUNC1, UBAP1, BRD7, NAG7, NOR1, NGX6 and LTF genes were found to be tumor suppressor/susceptibility genes in different stages of NPC. SPLUNC1, an early warning molecular diagnosis marker, inhibits the bacteria clone formation, and is an innated immune molecule. SPLUNC1 can negatively regulate the ERK/MAPK signaling transduction pathway to inhibit NPC cell proliferation and induce apoptosis. BRD7, a transcript regulation factor, interacts with BRD2, and promotes apoptosis induced by BRD2. Its promoter is regulated by c-Myc and SP1. BRD7 inhibits NPC cell cycle progression, preventing passage through G0/G1 by suppressing ras/MEK/ERK, Rb/E2F and Wnt signaling pathways. Abnormal activation of BRD7 is crucial to cell cycle turbulence in NPC. NGX6, a metastasis-associated protein, can negative-regulate the EGF/Ras/MAPK signaling transduction pathway, and interacts with ezrin protein to inhibit NPC cell invasion and metastasis. LTF, also a metastasis-associated protein, can negatively regulate MAPK signal transduction pathways, such as JNK2 and ERK, to inhibit NPC cell proliferation and growth. Taken together, it was found that these tumor suppressor/susceptibility genes can r...Continue Reading

Citations

Feb 18, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shiwei HeShuping Peng
Nov 1, 2011·Science China. Life Sciences·Zhaoyang ZengGuiyuan Li
Mar 10, 2011·International Journal of Cancer. Journal International Du Cancer·Victor Chun Lam WongMaria Li Lung
Dec 14, 2016·Journal of Cellular and Molecular Medicine·Xiao-Meng WangZhi-Ming Ge
Mar 31, 2020·Neurogenetics·Jianda WangJianhua Feng
Nov 8, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Young-Ae ParkDuk-Soo Bae
Dec 23, 2020·Computational Biology and Chemistry·Yi-Fan QiWen Liu

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
GTPase
biopsy
transfection

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Cycle Pathways

Cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of cell cycle and cell cycle pathways.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.