Signaling via IL-2 and IL-4 in JAK3-deficient severe combined immunodeficiency lymphocytes: JAK3-dependent and independent pathways.

Immunity
S A OakesJ J O'Shea

Abstract

Both IL-2 and IL-4 bind to receptors containing the common gamma chain and JAK3. Although JAK3 is required for proper lymphoid development, the precise roles of this kinase in IL-2 and IL-4 signaling in lymphocytes have not been defined. Here, we have studied IL-2 and IL-4 signaling in B cell lines lacking JAK3. Although IL-2-induced phosphorylation of IL-2R beta, JAK1, and STAT5 all required the presence of JAK3, IL-4-mediated phosphorylation of JAK1, STAT6, and insulin receptor substrates 1 and 2 did not. However, IL-4-induced effects were clearly improved following JAK3 expression. These data indicate that IL-4 signaling occurs in the absence of of JAK3, but is comparatively inefficient. These findings may help in understanding the pathogenesis of the immunodeficiency that occurs with mutations of JAK3 and may suggest a mechanism for the pleiotropic effects of IL-4.

Citations

Jun 10, 1998·Springer Seminars in Immunopathology·F CandottiA Villa
Jun 10, 1998·Springer Seminars in Immunopathology·F Candotti, R M Blaese
Apr 27, 2000·Molecular Immunology·K Imada, W J Leonard
Feb 24, 2001·Ryōikibetsu shōkōgun shirīzu·S Kumaki, S Tsuchiya
Aug 1, 1997·Current Opinion in Immunology·D C Thomis, L J Berg
Apr 1, 2000·Cytokine & Growth Factor Reviews·P M GrimleyH Rui
Dec 11, 1997·The New England Journal of Medicine·G K HersheyT A Chatila
Oct 15, 2003·The Journal of Experimental Medicine·Frank BlaeserTalal A Chatila
May 23, 1998·Annual Review of Immunology·A Henderson, K Calame
May 23, 1998·Annual Review of Immunology·W J Leonard, J J O'Shea
Jun 8, 2001·The Journal of Clinical Investigation·Y Abu-Amer
Jul 16, 2005·Blood·Kunihiro YamaokaJohn J O'shea
Aug 28, 2002·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Makoto Otsu, Fabio Candotti
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y J ZhouJ J O'Shea
Jan 6, 1999·Proceedings of the National Academy of Sciences of the United States of America·K D BuntingB P Sorrentino
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·M ChenJ J O'Shea
Feb 4, 2014·International Journal of Hematology·Fabio Candotti
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·S TakemotoG Franchini
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·C WofsyB Goldstein
Jan 24, 2015·The Journal of Investigative Dermatology·Tsung-Lin LeeChia-Chi Ku
Sep 11, 2007·The Journal of Allergy and Clinical Immunology·Evelina MazzolariLuigi D Notarangelo
Jan 22, 2005·Immunological Reviews·Marko PesuJohn J O'Shea
Dec 16, 2010·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Hidehiko MotegiJun-ichiro Inoue
Dec 29, 2000·Pediatric Clinics of North America·F Candotti
Jun 16, 2004·Immunological Investigations·Marta Benczik, Sarah L Gaffen
May 16, 2014·European Journal of Immunology·Aparna R ShenoyGeorg Häcker
Jan 22, 2011·Allergology International : Official Journal of the Japanese Society of Allergology·Hideyuki YamamotoShigeharu Fujieda
Jun 14, 2016·Mediators of Inflammation·Arturo Valle-MendiolaIsabel Soto-Cruz
May 20, 2016·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Kunihiro Yamaoka
Feb 3, 2007·Biochemical and Biophysical Research Communications·Hodaka Fujii

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