Signaling via major histocompatibility complex class II molecules and antigen receptors enhances the B cell response to gp39/CD40 ligand

European Journal of Immunology
Gail A BishopM T Berton

Abstract

Activated T cells induce proliferation and differentiation of resting B cells in vitro through their CD40 molecules and lymphokine receptors. However, despite constitutive B cell expression of CD40 and lymphokine receptors, widespread nonspecific polyclonal B cell activation by activated T cells is seldom observed in vivo. The present study was designed to test the hypothesis that signals delivered via the B cell antigen (Ag) receptor (membrane immunoglobulin, mIg) and major histocompatibility complex (MHC) class II molecules enhance B cell responsiveness to CD40-mediated signals, providing specificity to the Ag-nonspecific, MHC-unrestricted CD40 signal. To test this hypothesis, both an Ag-specific mouse B cell clone CH12.LX, and freshly isolated resting splenic B cells were cultured with either soluble or membrane-bound forms of the T cell ligand for CD40 (CD40L), in the presence or absence of additional signals provided by Ag or anti-IgM, interleukin-4, and class II-specific monoclonal antibody (mAb). Differentiation of CH12.LX cells and proliferation of splenic B cells in response to both forms of CD40L was greatly enhanced by exposure to mIg-mediated signals, with greatest enhancement seen when cells were cultured with Ag p...Continue Reading

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Citations

Nov 11, 1999·European Journal of Immunology·C LéveilléW Mourad
Jun 19, 2001·Current Opinion in Immunology·G A Bishop, B S Hostager
Jun 6, 2003·Cytokine & Growth Factor Reviews·Gail A Bishop, Bruce S Hostager
Mar 30, 2001·Cellular Immunology·G A BishopM A Tomai
Dec 30, 1998·Leukemia & Lymphoma·B K Link, G J Weiner
Dec 14, 2011·The Journal of Allergy and Clinical Immunology·Otavio Cabral-MarquesAntonio Condino-Neto
Aug 10, 2006·European Journal of Immunology·Rebecca J BensonGail A Bishop
Aug 24, 2010·Immunological Reviews·John P GrahamGail A Bishop
Mar 23, 2002·The Journal of Biological Chemistry·Kevin D BrownGail A Bishop
Oct 5, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Melissa E MunroeGail A Bishop
Jan 22, 2005·Immunological Reviews·Vassilios LougarisAlessandro Plebani
Jan 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Toufic O Nashar, James R Drake
Jan 5, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Melissa E Munroe, Gail A Bishop
Sep 29, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wesley A DunnickJohn T Collins
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S V JalukarG A Bishop
Nov 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K R Bobbitt, L B Justement
Jul 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sokol A HaxhinastoGail A Bishop
Oct 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sokol A Haxhinasto, Gail A Bishop
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bruce S Hostager, Gail A Bishop
Sep 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carissa R Moore, Gail A Bishop
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sonja M KnoetigHerbert C Morse
Jul 10, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Melissa E MunroeGail A Bishop
May 9, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·I M CatlettG A Bishop
Apr 21, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gail A Bishop
Apr 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ping XieGail A Bishop
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mekhine BaccamGail A Bishop
May 4, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jakrawadee JulamaneeHitoshi Kiyoi

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