Signaling via the Interleukin-10 Receptor Attenuates Cardiac Hypertrophy in Mice During Pressure Overload, but not Isoproterenol Infusion

Frontiers in Pharmacology
Nicholas StaffordDelvac Oceandy

Abstract

Inflammation plays a key role during cardiac hypertrophy and the development of heart failure. Interleukin-10 (IL-10) is a major anti-inflammatory cytokine that is expressed in the heart and may play a crucial role in cardiac remodeling. Based on the evidence that IL-10 potentially reduces pathological hypertrophy, it was hypothesized that signaling via the IL-10 receptor (IL10R) in the heart produces a protective role in reducing cardiac hypertrophy. The aim of this study was to investigate the effects of the ablation of Il-10-r1 gene during pathological cardiac hypertrophy in mice. We found that IL-10R1 gene silencing in cultured cardiomyocytes diminished the anti-hypertrophic effect of Il-10 in TNF-α induced hypertrophy model. We then analyzed mice deficient in the Il-10-r1 gene (IL-10R1-/- mice) and subjected them to transverse aortic constriction or isoproterenol infusion to induce pathological hypertrophy. In response to transverse aortic constriction for 2 weeks, IL-10R1-/- mice displayed a significant increase in the hypertrophic response as indicated by heart weight/body weight ratio, which was accompanied by significant increases in cardiomyocyte surface area and interstitial fibrosis. In contrast, there was no differ...Continue Reading

References

Jul 26, 1990·The New England Journal of Medicine·B LevineM Packer
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claudia NiemandGerhard Müller-Newen
Apr 15, 2004·Genesis : the Journal of Genetics and Development·Martin HafnerWerner Müller
Oct 27, 2004·Immunology·Lynn M WilliamsBrian M J Foxwell
Feb 16, 2005·Circulation·Sofie P M JanssenMarc Decramer
Oct 2, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Sanjiv DhingraPawan K Singal
Jul 5, 2008·European Journal of Heart Failure·Christian StumpfChristoph D Garlichs
Jan 24, 2009·Immunological Reviews·David M Mosser, Xia Zhang
Feb 3, 2009·Cardiovascular Research·Sanjiv DhingraPawan K Singal
Nov 27, 2009·European Journal of Immunology·Marina C PilsWerner Müller
Feb 1, 2011·Trends in Molecular Medicine·Shirin Doroudgar, Christopher C Glembotski
May 8, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Benjamin W Van TassellAntonio Abbate
Jul 24, 2013·Circulation·Jana S BurchfieldJoseph A Hill
Jan 15, 2014·Seminars in Immunology·Jeffrey J BabonNicos A Nicola
Dec 19, 2014·Circulation·Dariush MozaffarianUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Mar 31, 2015·Circulation Research·Douglas L Mann
Nov 10, 2015·Journal of Molecular and Cellular Cardiology·Raj KishoreSuresh Kumar Verma
Jun 25, 2016·Circulation Research·Sumanth D Prabhu, Nikolaos G Frangogiannis
May 12, 2018·Circulation. Arrhythmia and Electrophysiology·Hidekazu KondoNaohiko Takahashi
Mar 20, 2019·Basic Research in Cardiology·Lucas BacmeisterDiana Lindner
Jan 24, 2020·Nature Reviews. Cardiology·Luigi AdamoDouglas L Mann

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Jul 25, 2021·International Journal of Molecular Sciences·Fernanda GubertGisele Zapata-Sudo

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