Signalling by protein phosphatases and drug development: a systems-centred view.

The FEBS Journal
Lan K NguyenBoris N Kholodenko

Abstract

Protein modification cycles catalysed by opposing enzymes, such as kinases and phosphatases, form the backbone of signalling networks. Although, historically, kinases have been at the research forefront, a systems-centred approach reveals predominant roles for phosphatases in controlling the network response times and spatio-temporal profiles of signalling activities. Emerging evidence suggests that phosphatase kinetics are critical for network function and cell-fate decisions. Protein phosphatases operate as both immediate and delayed regulators of signal transduction, capable of attenuating or amplifying signalling. This versatility of phosphatase action emphasizes the need for systems biology approaches to understand cellular signalling networks and predict the cellular outcomes of combinatorial drug interventions.

References

Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·G PagèsJ Pouysségur
Jan 15, 1999·Science·U S Bhalla, R Iyengar
Mar 19, 1999·Molecular and Cellular Biology·H J Schaeffer, M J Weber
Mar 25, 1999·Cell·T CasciM Freeman
Sep 3, 1999·FEBS Letters·G C Brown, B N Kholodenko
Oct 9, 1999·The Journal of Biological Chemistry·B N KholodenkoJ B Hoek
May 10, 2000·The Journal of Biological Chemistry·D AbrahamM Baccarini
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·Y Yarden, M X Sliwkowski
Feb 15, 2002·Biological Chemistry·P O HackelA Ullrich
Apr 30, 2002·Trends in Cell Biology·Boris N Kholodenko
Jun 7, 2002·Molecular Cell·Reinhart HeinrichTom A Rapoport
Jan 28, 2003·The Journal of Biological Chemistry·Jin-Peng SunZhong-Yin Zhang
Mar 11, 2003·American Journal of Physiology. Endocrinology and Metabolism·Ernest Asante-Appiah, Brian P Kennedy
Apr 30, 2003·Nature Cell Biology·Andrew R ReynoldsPhilippe I H Bastiaens
Jun 10, 2004·Cell·Andres AlonsoTomas Mustelin
Oct 12, 2004·Molecular Pharmacology·David V ErbeJames F Tobin
Dec 3, 2004·The Journal of Biological Chemistry·Alexandra MontagnerPatrick Raynal
Dec 17, 2004·Journal of Bacteriology·Karen LipkowDennis Bray
Apr 9, 2005·The Journal of Endocrinology·Andrew W Stoker
Jun 1, 2005·Biophysical Journal·Nikolay M BorisovBoris N Kholodenko
Aug 2, 2005·European Journal of Medical Genetics·Marco Tartaglia, Bruce D Gelb
Feb 17, 2006·Nature Reviews. Molecular Cell Biology·Boris N Kholodenko
Jul 11, 2006·Current Opinion in Chemical Biology·Carolyn R ChoManuel C Peitsch
Oct 24, 2006·Nature Reviews. Molecular Cell Biology·Nicholas K Tonks

❮ Previous
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Citations

Mar 17, 2015·FEBS Letters·Teri HatzihristidisDiego Miranda-Saavedra
Oct 21, 2016·IET Systems Biology·Peter J Gawthrop, Edmund J Crampin
Nov 12, 2013·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Drieke VandammeWalter Kolch
Jan 28, 2015·Biochemical and Biophysical Research Communications·Zhaohong QinHsiao-Huei Chen
Dec 17, 2014·Computers & Chemical Engineering·Shibin Mathew, Ipsita Banerjee
Sep 1, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Tsukasa Igawa
Jan 21, 2017·Integrative Biology : Quantitative Biosciences From Nano to Macro·Tamas KorcsmarosGiulio Superti-Furga
Mar 7, 2018·British Journal of Pharmacology·Jordan F HastingsThomas R Cox
Oct 19, 2017·Journal of Biomolecular Structure & Dynamics·Rajan PandeyDinesh Gupta
Jan 22, 2019·The FEBS Journal·Yu-Lu WangZhi-Xin Wang
Jan 19, 2019·Psychopharmacology·Emma N Cahill, Amy L Milton
May 5, 2018·Cellular and Molecular Life Sciences : CMLS·Goutham NarlaChristopher B Ryder
Jan 13, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Michael E PriceTodd A Wyatt
Jul 25, 2019·Current Molecular Pharmacology·Ajay KumarRohit Bhatia
Dec 11, 2019·International Journal of Molecular Sciences·Jain HaSayeon Cho
Dec 9, 2020·Cancer Letters·Pegah AbdollahiMagne Børset
Sep 6, 2019·Translational Research : the Journal of Laboratory and Clinical Medicine·Worapol Ngamcherdtrakul, Wassana Yantasee

❮ Previous
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