Signalling elements in the ultradian rhythm of circulating growth hormone regulating expression of sex-dependent forms of hepatic cytochrome P450

Endocrinology
Bernard H ShapiroD J Waxman

Abstract

Neonatal male rats were treated with monosodium glutamate (MSG) at either 2 or 4 mg/g BW on alternate days during the first 10 days of life. As adults, the 4 mg MSG-treated rats displayed the obesity, growth retardation, and reduced pituitary weights that typify this syndrome. These animals had no detectable plasma GH as determined from serial blood samples taken every 20 min for 8 consecutive h. Associated with this loss of circulating GH was an induction of the female-specific hepatic cytochrome P450 2d (gene IIC12) and the disappearance of the male-specific form of cytochrome P450 2c (gene IIC11). The catalytic activities of cytochrome P450 2c (i.e. androgen 16 alpha- and 2 alpha-hydroxylase), sex-dependent hexobarbital hydroxylase and total cytochrome P450 were similarly feminized. Rats exposed to the 2-mg dose of MSG were also obese, but their growth rates and pituitary sizes were not as severely affected as in the 4 mg MSG-treated rats. Circulating GH in these lower dosed males was secreted in a pulsatile pattern similar to that in normal males, except that the pulse amplitude was reduced as much as 90%. In spite of this profound decline in GH peak heights in the 2 mg MSG-treated males, liver metabolism was characteristic...Continue Reading

Citations

Sep 1, 1993·Biochemical Pharmacology·N A Pampori, B H Shapiro
Jan 1, 1991·Pharmacology & Therapeutics·M H Hastings
Jan 1, 1995·The International Journal of Biochemistry & Cell Biology·B H ShapiroN A Pampori
Feb 27, 2001·Molecular and Cellular Endocrinology·A K Agrawal, B H Shapiro
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P BullockA Parkinson
Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·D J WaxmanB H Shapiro
Oct 19, 2012·The Journal of Endocrinology·Rajat Kumar DasBernard H Shapiro
Nov 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ravindra N Dhir, Bernard H Shapiro
Jan 11, 2003·American Journal of Therapeutics·Joseph Prandota
Feb 24, 2015·Toxicology and Applied Pharmacology·Sarmistha BanerjeeBernard H Shapiro
Sep 18, 2007·Biochemical Pharmacology·Chellappagounder ThangavelBernard H Shapiro
Dec 27, 2005·Toxicology·Kanokwan JarukamjornNobuo Nemoto
Mar 21, 2006·Drug Metabolism and Pharmacokinetics·Kanokwan JarukamjornNobuo Nemoto
Dec 17, 2016·The Journal of Endocrinology·Rajat K DasBernard H Shapiro
Jun 20, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rajat Kumar DasBernard H Shapiro
Jan 7, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Arun K Agrawal, Bernard H Shapiro
Feb 5, 2003·The Journal of Biological Chemistry·Colin J HendersonC Roland Wolf
Aug 16, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Meena R SharmaBernard H Shapiro
Apr 30, 1999·Physiological Reviews·E E MüllerD Cocchi
May 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·D M Keenan, J D Veldhuis
Jan 17, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Ravindra N DhirBernard H Shapiro
Dec 1, 1993·Metabolism: Clinical and Experimental·Z HochbergT Amit

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