Signalling mechanisms and oxidative stress in apoptosis

Toxicology Letters
A F SlaterS Orrenius

Abstract

A variety of stimuli can induce cells to undergo apoptotic death. One of the most reproducible inducers is mild oxidative stress, be it via exposure to hydrogen peroxide, redox-cycling quinones or thiol-alkylating agents. Oxidative modifications of proteins and lipids have also been observed in cells undergoing apoptosis in response to non-oxidative stimuli such as glucocorticoids or topoisomerase II inhibitors. This suggests that some unidentified oxidative changes occur during apoptosis in many, if not all, cases. However, recent experiments demonstrating apparently normal apoptosis even when cells are cultured at low oxygen tensions show that reactive oxygen species cannot be essential mediators of this type of cell death. Experiments revealing that apoptosis is typically accompanied by a depletion of intracellular reduced glutathione (GSH) are also discussed. As GSH depletion will lower a cell's capacity to buffer against endogenous oxidants, we propose that it contributes to the increased oxidative damage commonly observed to accompany apoptosis. In addition, it may set a time limit on continued mitochondrial function (and thus indirectly on total ATP levels and membrane integrity) in apoptotic cells, and thereby explain t...Continue Reading

References

Jan 1, 1980·International Review of Cytology·A H WyllieA R Currie
Oct 22, 1993·Cell·D M HockenberyS J Korsmeyer
Apr 27, 1995·Nature·M D Jacobson, M C Raff
May 1, 1995·Trends in Biochemical Sciences·S Kumar
Apr 27, 1995·Nature·S ShimizuY Tsujimoto
Aug 17, 1994·Biochemical Pharmacology·R S Fernandes, T G Cotter
Jan 1, 1994·The Journal of Cell Biology·J C Reed
Jan 1, 1993·Archives of Biochemistry and Biophysics·M A Barry, A Eastman

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Citations

Dec 15, 2000·Medical Oncology·K HellstrandP Naredi
Mar 11, 1998·Biological Trace Element Research·M O ParatA Favier
Mar 28, 2003·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Zongquan Sun Hasichaolu
Nov 18, 2010·Apoptosis : an International Journal on Programmed Cell Death·Jayaraj RavindranP V Lakshmana Rao
Mar 21, 1998·Pharmacology & Therapeutics·M Raffray, G M Cohen
Mar 1, 2003·International Journal of Immunopharmacology·C D MorganJ W Measel
Mar 27, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Arun K RainaMark A Smith
Mar 1, 2002·Toxicology Letters·R BhattacharyaR Vijayaraghavan
Jul 12, 2002·Toxicology in Vitro : an International Journal Published in Association with BIBRA·D TrisciuoglioO Sapora
Mar 26, 2003·Toxicology in Vitro : an International Journal Published in Association with BIBRA·T CimboraM Osmak
Apr 16, 1998·Reproductive Toxicology·C Strandgaard, M G Miller
Apr 23, 2003·Free Radical Biology & Medicine·Marina ComelliIrene Mavelli
Oct 30, 2003·Free Radical Biology & Medicine·Jianfei JiangValerian E Kagan
Sep 1, 1996·Research in Immunology·J P Abastado
Mar 16, 2013·Chemical Reviews·Sonja EckhardtKatharina M Fromm
Sep 8, 1999·The Biochemical Journal·Y Morel, R Barouki
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·R J DuhéW L Farrar
Oct 26, 2013·The Journal of Biological Chemistry·Andrew D JamesJason I E Bruce
Feb 10, 2006·Korean Journal of Biological Sciences·Quan ChenAlex Almasan
Mar 12, 2011·Antioxidants & Redox Signaling·Valerio Chiurchiù, Mauro Maccarrone
Jun 24, 1998·Journal of the National Cancer Institute·T J DoughertyQ Peng
Mar 4, 2000·Alcoholism, Clinical and Experimental Research·L J MiC S Lieber
Dec 17, 2002·Molecular and Cellular Biology·Jijun ChengXiang S Ye
Jul 14, 2005·Annual Review of Nutrition·Archana Jaiswal McEligotFrank L Meyskens
Jan 28, 2004·Annual Review of Pharmacology and Toxicology·James E Klaunig, Lisa M Kamendulis
Sep 21, 2012·American Journal of Physiology. Cell Physiology·Michael B McFerrinHarald Sontheimer

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