Signalling pathways in the nitric oxide donor-induced dopamine release in the striatum of freely moving rats: evidence that exogenous nitric oxide promotes Ca2+ entry through store-operated channels

Brain Research
Gaia RocchittaPier Andrea Serra

Abstract

We showed previously, using in vitro microdialysis, that the activation of the soluble guanylate cyclase (sGC)/cyclic GMP pathway was the underlying mechanism of the extracellular Ca(2+)-dependent effects of exogenous NO on dopamine (DA) secretion from PC12 cells. In this study, the co-infusion of the sGC inhibitor 1H-[1,2,4]oxadiazolo[4,3] quinoxalin-1-one (ODQ) failed to affect the NO donor 3-morpholinosydnonimine (SIN-1, 5.0 mM)-induced DA increase (sevenfold baseline) in dialysates from the striatum of freely moving rats. Ca(2+) omission from the perfusion fluid abolished baseline DA release but did not affect SIN-1-induced DA increases. The reintroduction of Ca(2+) in the perfusion fluid restored the baseline dialysate DA; however, when Ca(2+) reintroduction was associated with the infusion of either SIN-1 or the NO-donor S-nitrosoglutathione (SNOG), a sustained DA overflow was observed. DA overflow was selectively inhibited by the co-infusion of the store-operated channel blocker 2-aminoethoxydiphenyl borate. The chelation of intracellular Ca(2+) by co-infusing 1,2-bis (o-amino-phenoxy)ethane-N,N,N',N'-tetraacetic acid tetra (acetoxymethyl) ester (BAPTA-AM, 0.2 mM) greatly potentiated both SIN-1- and SNOG-induced increase...Continue Reading

References

Jan 1, 1986·Annual Review of Neuroscience·L Stryer
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R G KnowlesS Moncada
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Nov 1, 1995·Journal of Neurochemistry·H IschiropoulosJ Horwitz
Jan 27, 1995·Cell·D E Clapham
Feb 1, 1994·Journal of Neurochemistry·R Guevara-GuzmanK M Kendrick
Jun 1, 1993·Journal of Neuroscience Research·G LonartK M Johnson
Sep 1, 1995·Cell Calcium·E A Milbourne, F L Bygrave
Aug 1, 1996·Analytical Chemistry·M N FriedemannG A Gerhardt
Nov 14, 1997·Physiological Reviews·A B Parekh, R Penner
Feb 24, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P RauhalaC C Chiueh
Nov 13, 1998·The Journal of Biological Chemistry·C J FavreD L Gill
Jan 29, 1999·BMJ : British Medical Journal·A H Schapira
Mar 19, 1999·Neuroscience Letters·S Hussain, S F Ali
Jul 3, 1999·Physiological Reviews·A MeirR Rahamimoff
Dec 10, 1999·The Journal of Biological Chemistry·H T MaD L Gill
Aug 3, 2002·Nature Reviews. Neuroscience·Josep Rizo, Thomas C Südhof
Oct 9, 2002·The Biochemical Journal·Robert G KeynesJohn Garthwaite
Nov 2, 2002·British Journal of Pharmacology·Baskaran ThyagarajanKlaus Groschner
Dec 17, 2002·Methods in Enzymology·Tara P Dasgupta, James N Smith
Mar 27, 2003·Journal of Neural Transmission·M T SilvaP Jenner

❮ Previous
Next ❯

Citations

Oct 26, 2010·Journal of Physiology and Biochemistry·Vallo MattoSulev Kõks
Apr 22, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Henrike HartungStephanie J Cragg
Oct 27, 2007·Experimental Eye Research·Foteini KiagiadakiKyriaki Thermos
Nov 28, 2006·Nitric Oxide : Biology and Chemistry·Hiroyasu TsutsukiHideshi Ihara
Feb 2, 2008·Methods in Enzymology·Ian R Davies, Xueji Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.