Signalling pathways involved in oocyte growth, acquisition of competence and activation

Human Fertility : Journal of the British Fertility Society
Cláudia NunesMargarida Fardilha

Abstract

The oocyte's primary function is to be fertilised by a spermatozoon in order to create a viable embryo. Oocyte growth and development are initiated during embryogenesis and occur in parallel to follicular development. Factors produced by the oocyte bind to receptors on follicular cells, ensuring follicular development. Oocytes begin meiosis during foetal development and are arrested in prophase I by elevated levels of cyclic adenosine monophosphate (cAMP). Activation of mitogen-activated protein kinases triggers degradation of cAMP, allowing oocyte maturation to proceed. The production of progesterone and prostaglandins during the ovulation process ultimately activates proteases, whose action helps to release the oocyte into the Fallopian tube. Oocyte activation depends on fertilisation and is induced by changes in intracellular calcium levels. Dysregulation of these pathways is involved in the pathogenesis of several diseases including the syndrome of oocyte maturation failure.

References

Jun 4, 2002·Human Reproduction·David LevranAriel Weissman
Oct 31, 2003·Human Reproduction·Milan Mrazek, Josef Fulka
Mar 12, 2004·Nature·Joshua JohnsonJonathan L Tilly
Sep 4, 2004·Reproductive Biology and Endocrinology : RB&E·María GaytanFrancisco Gaytan
Jul 30, 2005·Molecular Endocrinology·Marco ContiYou-Qiang Su
Sep 12, 2007·Journal of Assisted Reproduction and Genetics·Junichi HasegawaTakashi Okai
Oct 24, 2007·Human Reproduction·P FeuersteinD Royere
Jan 8, 2008·Human Reproduction Update·Robert B GilchristJeremy G Thompson
Jan 11, 2008·Biology of Reproduction·Andrea DiLuigiLisa M Mehlmann
Jul 8, 2008·Developmental Biology·George B JohnDiego H Castrillon
Jul 8, 2008·Human Reproduction Update·Jason E Swain, Thomas B Pool
May 6, 2009·Reproductive Biology and Endocrinology : RB&E·Alberto RevelliPaolo Rinaudo
Jul 16, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·R A AndersonS Pickering
Oct 10, 2009·Molecular Human Reproduction·Jaeyeon KimMilan K Bagchi
Oct 15, 2009·Human Reproduction Update·Jay M Baltz, Alina P Tartia
Oct 24, 2009·Journal of Reproductive Immunology·Satish K GuptaKausiki Chakrabarti
Jan 21, 2010·Nuclear Receptor Signaling·Rebecca L RobkerDarryl L Russell
Apr 10, 2010·Fertility and Sterility·Stephanie BeallJames Segars
Apr 27, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Min Han
Jun 18, 2010·Canadian Journal of Physiology and Pharmacology·Gerald M Kidder, Barbara C Vanderhyden
Jul 27, 2010·Molecular and Cellular Endocrinology·Yuval YungAriel Hourvitz
Sep 10, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Rachael P NorrisLaurinda A Jaffe
Nov 3, 2010·Reproductive Biology and Endocrinology : RB&E·Diane M DuffyLane K Christenson
Dec 9, 2010·Development·Georg Halder, Randy L Johnson
Mar 30, 2011·Human Reproduction Update·Maurizio ZuccottiSilvia Garagna
Jun 18, 2011·Molecular Reproduction and Development·Lynda K McGinnisWilliam H Kinsey
Jul 19, 2011·Journal of Assisted Reproduction and Genetics·Fang-Ting KuoMargareta D Pisarska
Sep 14, 2011·Molecular Human Reproduction·David G MottersheadRobert B Gilchrist
Nov 29, 2011·Methods in Cell Biology·Brian D GeldzilerAndrew Singson
Jan 13, 2012·PLoS Computational Biology·Benjamin PfeutyMarc Lefranc
Apr 28, 2012·Biology of Reproduction·Betty Y KongTeresa K Woodruff
Jun 15, 2012·Journal of Assisted Reproduction and Genetics·Yasuyuki MioKyoko Nishikori
Jul 31, 2012·PLoS Genetics·Dori C WoodsJonathan L Tilly
Aug 14, 2012·Molecular Reproduction and Development·Yi-Liang Miao, Carmen J Williams

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Citations

Sep 15, 2016·Frontiers in Physiology·Isabella Ellinger
Oct 30, 2016·Journal of Cellular Physiology·Meenakshi TiwariShail K Chaube
Oct 22, 2015·Scientific Reports·Marshall DelineJennifer L Watts
Sep 5, 2019·Reproduction in Domestic Animals = Zuchthygiene·Leda Maria Costa PereiraMaria Denise Lopes
Aug 31, 2021·Computational Biology and Chemistry·Neda Daei-FarshbafMehrdad Bakhtiyari

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