PMID: 9176016May 1, 1997Paper

Signalling pathways involved in the mitogenic effects of cAMP

Clinical Science
D J Withers

Abstract

1. Elevation of intracellular cyclic AMP (cAMP) is a potent mitogenic signal for a number of cell types, including Swiss 3T3 cells, thyroid epithelial cells and the somatotroph cells of the anterior pituitary. 2. Activation of the mitogen-activated protein kinase (MAPK) cascade has been shown to underlie the mitogenic effects of many growth factors. However, the precise relationship between the mitogenic effects of cAMP and the MAPK cascade is not fully defined. 3. In Swiss 3T3 cells, elevation of cAMP did not stimulate kinases at all three levels of the MAPK cascade. Additionally, blockade of the MAPK pathway failed to inhibit cAMP-stimulated DNA synthesis. 4. Mitogenic combinations of cAMP strongly stimulated the phosphorylation and activation of the serine/threonine kinase p70 S6 kinase, p70S6K, an effect that was inhibited by rapamycin. This agent markedly inhibited cAMP-stimulated DNA synthesis, suggesting a critical role for p70S6K in cAMP mitogenic signalling. 5. Thus, multiple parallel but distinct signalling pathways may be involved in the action of mitogens. This redundancy has important implications for the pathogenesis and treatment of conditions characterized by inappropriate activation of growth factor signalling ...Continue Reading

Citations

Jul 10, 2003·Biochemical and Biophysical Research Communications·Jan LyngeYlva Hellsten
May 23, 2014·Molecular and Cellular Endocrinology·R Formosa, J Vassallo
Feb 8, 2002·Evolution; International Journal of Organic Evolution·M F Antolin, J M Herbers
Jul 22, 2018·Cell Proliferation·M E M S KhedrS I Khakoo
Nov 5, 2019·Molecular and Cellular Endocrinology·Marthe Rizk-RabinJerôme Bertherat
Apr 16, 1998·Biochemical and Biophysical Research Communications·Y H LeeS K Lee
Jul 2, 2003·Cellular Signalling·Gunnar Schulte, Bertil B Fredholm

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