Signalment risk factors for cutaneous and renal glomerular vasculopathy (Alabama rot) in dogs in the UK

The Veterinary Record
Kim B StevensJacqueline Martina Cardwell

Abstract

Seasonal outbreaks of cutaneous and renal glomerular vasculopathy (CRGV) have been reported annually in UK dogs since 2012, yet the aetiology of the disease remains unknown. The objectives of this study were to explore whether any breeds had an increased or decreased risk of being diagnosed with CRGV, and to report on age and sex distributions of CRGV cases occurring in the UK. Multivariable logistic regression was used to compare 101 dogs diagnosed with CRGV between November 2012 and May 2017 with a denominator population of 446,453 dogs from the VetCompass database. Two Kennel Club breed groups-hounds (odds ratio (OR) 10.68) and gun dogs (OR 9.69)-had the highest risk of being diagnosed with CRGV compared with terriers, while toy dogs were absent from among CRGV cases. Females were more likely to be diagnosed with CRGV (OR 1.51) as were neutered dogs (OR 3.36). As well as helping veterinarians develop an index of suspicion for the disease, better understanding of the signalment risk factors may assist in the development of causal models for CRGV and help identify the aetiology of the disease.

References

Nov 1, 1988·Veterinary Pathology·J L CarpenterN W King
Feb 17, 2000·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·R W Hertle, L F Dell'Osso
Feb 5, 2010·Preventive Veterinary Medicine·Paul C BartlettChun Zhou
Jan 27, 2012·The Veterinary Record·J A C Oliver, D J Gould
Mar 7, 2014·The Journal of Small Animal Practice·Madeleine MattinDave Brodbelt
Aug 15, 2014·The New England Journal of Medicine·James N George, Carla M Nester
Aug 31, 2018·Revue Scientifique Et Technique·M MartiniR Busetto

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Citations

Oct 14, 2018·The Veterinary Record·Suzanne Jarvis
Mar 23, 2021·Canine Medicine and Genetics·Grace L EdmundsDan G O'Neill
Apr 9, 2021·The Veterinary Record·Joshua James Allen WalkerDavid John Walker
Apr 26, 2021·Journal of Comparative Pathology·Vera PiscoDavid J Walker
Jun 1, 2021·The Veterinary Record·Collette TaylorDave C Brodbelt

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