Signals involved in mycobacteria-induced CXCL-8 production by human monocytes

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
Patricia Méndez-SamperioA Vázquez

Abstract

CXC chemokine-interleukin-8 (IL-8) (CXCL-8) is a potent proinflammatory chemotactic factor that induces important immune responses for antimycobacterial defenses. However, little is known about the biochemical mechanisms by which the mycobacterial antigens upregulate the release of CXCL-8 from human monocytes. In this study, the mechanisms through which Mycobacterium bovis BCG induces CXCL-8 secretion in human monocytes were investigated. We found that M. bovis BCG induced the production of high levels of CXCL-8 by human monocytes. M. bovis-induced CXCL-8 secretion was unaffected by the protein kinase C (PKC) inhibitor bisindolylmaleimide. In contrast, preincubation of the monocytes with the protein tyrosine kinase (PTK) inhibitor genistein resulted in dose-dependent suppression of mycobacteria-induced CXCL-8 secretion. These results were further supported by the fact that treatment of monocytes with herbimycin-A, another well-described inhibitor of PTK activity with a different mechanism of action, significantly diminished the effect of M. bovis on CXCL-8 secretion. In addition, the specificity of this inhibition was demonstrated by the inability of herbimycin-A to block in a significant manner IL-1 beta induction of CXCL-8. H...Continue Reading

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Citations

Jul 16, 2003·The Journal of Infection·P Méndez-SamperioH Ayala
Mar 17, 2005·Mediators of Inflammation·Patricia Méndez SamperioElena Miranda
Jul 26, 2006·Mediators of Inflammation·Patricia Méndez-SamperioAbraham Vázquez
Jul 31, 2002·The Journal of Cell Biology·David G RussellElizabeth E Rhoades
Oct 8, 2008·The Journal of Infection·Patricia Méndez-Samperio

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