Signature of circulating microRNAs in patients with acute heart failure.

European Journal of Heart Failure
Ekaterina S OvchinnikovaEugene Berezikov

Abstract

Our aim was to identify circulating microRNAs (miRNAs) associated with acute heart failure (AHF). Plasma miRNA profiling included 137 patients with AHF from 3 different cohorts, 20 with chronic heart failure (CHF), 8 with acute exacerbation of COPD, and 41 healthy controls. Levels of circulating miRNAs were measured using quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Plasma levels of miRNAs in patients with AHF were decreased compared with CHF patients or healthy subjects, whereas no significant changes were observed between acute COPD patients and controls. Fifteen miRNAs found in the discovery phase to differ most significantly between healthy controls and patients with AHF were further investigated in an extended cohort of 100 AHF patients at admission and a separate cohort of 18 AHF patients at different time points. Out of these 15 miRNAs, 12 could be confirmed in an additional AHF validation cohort and 7 passed the Bonferroni correction threshold (miR-18a-5p, miR-26b-5p, miR-27a-3p, miR-30e-5p, miR-106a-5p, miR-199a-3p, and miR-652-3p, all P < 0.00005). A further drop in miRNA levels within 48 h after AHF admission was associated with an increased risk of 180-day mortality in a subset of the iden...Continue Reading

References

May 15, 2007·Journal of Molecular and Cellular Cardiology·Mariko TatsuguchiDa-Zhi Wang
Feb 8, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jian-Fu ChenDa-Zhi Wang
Sep 12, 2009·Clinical Chemistry·Omar F LaterzaWarren E Glaab
Feb 27, 2010·Circulation Research·Anke J TijsenYigal M Pinto
Apr 3, 2010·Circulation Research·David W Markham, Joseph A Hill
May 21, 2010·Physiological Genomics·Christine VoellenkleFabio Martelli
Oct 6, 2010·Circulation. Cardiovascular Genetics·Maarten F CorstenBlanche Schroen
Dec 16, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasue FukushimaNaoharu Iwai
Jun 8, 2011·Nature Reviews. Clinical Oncology·Maria Angelica CortezGeorge A Calin
Aug 2, 2011·Journal of Molecular and Cellular Cardiology·Claudia JentzschStefan Engelhardt
Oct 5, 2011·Circulation·Salvatore De RosaAndreas M Zeiher
Oct 5, 2011·The Journal of Biological Chemistry·Manvendra K SinghJonathan A Epstein
Nov 29, 2011·European Journal of Heart Failure·Yaron GorenOffer Amir
Sep 5, 2012·Trends in Biochemical Sciences·Andrey TurchinovichBarbara Burwinkel
Apr 2, 2013·The Journal of Clinical Investigation·Xiaobin LuoStanley Nattel
May 11, 2013·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Dong-Sheng ZhaoQi-Jun Shan
May 23, 2013·European Journal of Heart Failure·Katrina L EllisA Mark Richards
Jul 3, 2013·Journal of Cardiothoracic Surgery·Enshi WangZhe Zheng
Jul 19, 2013·European Heart Journal·Britta VogelBenjamin Meder
Apr 8, 2014·PloS One·Hiroko Ogata-KawataNaoto Tsuchiya
Aug 16, 2014·International Journal of Cardiology·Anna P PilbrowRoger S-Y Foo
Aug 26, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bianca C BernardoJulie R McMullen
Oct 29, 2014·Journal of the American Heart Association·Felix JansenNikos Werner
Jan 27, 2015·European Journal of Heart Failure·Lee Lee WongArthur Mark Richards
Feb 3, 2015·Journal of Cardiovascular Medicine·Huseyin Altug CakmakVural Ali Vural
Mar 6, 2015·European Journal of Heart Failure·Chris J WatsonThomas Thum
Apr 2, 2015·European Journal of Heart Failure·Daniela SchmitterPim van der Harst

❮ Previous
Next ❯

Citations

Feb 13, 2016·European Journal of Heart Failure·Eline L VegterAdriaan A Voors
Dec 2, 2015·Artificial Cells, Nanomedicine, and Biotechnology·Qiang LiuJiasheng Fang
Nov 17, 2015·International Journal of Cardiology·Noemi BrunoAdriaan A Voors
May 21, 2016·European Journal of Heart Failure·Marco Metra
Aug 31, 2016·Trends in Cardiovascular Medicine·Ravi Dhingra, Ramachandran S Vasan
Apr 14, 2016·European Journal of Heart Failure·Francine Z MarquesDavid M Kaye
Oct 25, 2016·International Journal of Cardiology·Eline L VegterMohsin A F Khan
Dec 6, 2016·International Journal of Molecular Sciences·Ilaria FlorisIllimar Altosaar
Feb 20, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Junjie XiaoSaumya Das
Jun 7, 2017·European Journal of Heart Failure·Marco Metra
Mar 16, 2017·Archivos de cardiología de México·Luis Alejandro Arias Sosa
Mar 8, 2018·Heart Failure Reviews·Michele CorrealeUNKNOWN Master Program Students on Drug Development for Heart Failure
Sep 28, 2017·European Journal of Heart Failure·Nick van BovenDouwe Postmus
Sep 28, 2017·European Journal of Heart Failure·Lee Lee Wong, Arthur Mark Richards
Feb 2, 2018·European Journal of Heart Failure·Marco Metra
Apr 18, 2018·Critical Reviews in Clinical Laboratory Sciences·Arnold PiekHerman H W Silljé
Mar 9, 2018·European Journal of Heart Failure·Roberto FerrariLuigi Tavazzi
Nov 14, 2017·ESC Heart Failure·Amir EmamiStephan von Haehling
Oct 27, 2017·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C M KanetoP S P Lima
Jun 12, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Kyoung-Mi ParkIl-Man Kim
Jun 8, 2018·Acta Pharmacologica Sinica·Shan-Shan ZhouLu Cai
Jan 21, 2017·Circulation Research·Janika Viereck, Thomas Thum
Oct 23, 2018·Genetic Testing and Molecular Biomarkers·Serap Tutgun OnratAlaettin Avşar
Oct 27, 2017·European Heart Journal·Sarah CostantinoFrancesco Paneni
Dec 21, 2018·ESC Heart Failure·Elisabetta DinatoloMarco Metra
Dec 15, 2018·Current Opinion in Cardiology·Pishoy Gouda, Justin A Ezekowitz
Dec 21, 2018·Journal of Applied Physiology·Glenn D WadleyBianca C Bernardo
Oct 4, 2019·Biomarkers in Medicine·Leili PourafkariNader D Nader
Nov 15, 2019·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Ping YangZhongcai Fan
Dec 29, 2019·European Journal of Heart Failure·Markus S AnkerStefan D Anker
Dec 31, 2019·ESC Heart Failure·Markus S AnkerWilhelm Haverkamp
Feb 15, 2019·Clinical Epigenetics·Xiao WangBengt Zöller
Oct 16, 2019·Journal of Clinical Pathology·Giuditta BenincasaClaudio Napoli
Dec 5, 2019·Journal of Occupational and Environmental Medicine·Thomas H ThatcherMark J Utell
Dec 5, 2019·Journal of Occupational and Environmental Medicine·Collynn F WoellerMark J Utell
Oct 11, 2019·PloS One·Masood Abu-HalimaTanja Raedle-Hurst
Sep 5, 2020·Journal of Cellular and Molecular Medicine·Mengdie ChengHui Xin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Argentine Hemorrhagic Fever

Argentine hemorrhagic fever (AHF) is an endemo-epidemic disease caused by junín virus (JUNV), a member of the arenaviridae family. Discover the latest research on AHF here.