Signatures of balancing selection in toll-like receptor (TLRs) genes - novel insights from a free-living rodent

Scientific Reports
Agnieszka KlochStuart B Piertney

Abstract

Selective pressure from pathogens is considered a key selective force driving the evolution of components of the immune system. Since single components of the immune system may interact with many pathogens, and single pathogens may be recognized by multiple components of the immune system, gaining a better understanding of the mechanisms of parasite-driven selection requires the study of multiple genes and pathogens. Toll-like receptors (TLRs) are a large gene family that code for antigen-presenting components of the innate immune response. In the present paper we characterize polymorphism and signatures of selection in seven TLRs in free-living bank voles Myodes glareolus. We report the first evidence of balancing selection in several TLR genes, supported by positive values of Fu and Li's D* in TLR2 and TLR5, and positive values of Tajima's D in LRR regions within TLR1 and TLR2. We further found significant associations between amino-acid alleles of TLR1 and TLR5 and susceptibility to infection with the blood pathogen Bartonella. Interestingly, selection patterns in TLRs presenting virus-derived motifs (TLR7 and TLR9) differed considerably from those interacting with bacterial PAMPs. In contrast to the highly variable TLRs pre...Continue Reading

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Citations

Sep 11, 2019·Genome Biology and Evolution·Joanne R ChapmanRobert L Unckless
Dec 5, 2019·Genome Biology and Evolution·Guangshuai LiuHonghai Zhang
Feb 26, 2020·Molecular Biology and Evolution·Hila LevyAdrian L Smith
Mar 12, 2020·Scientific Reports·Erwan QuéméréEmmanuelle Gilot-Fromont
May 23, 2019·BMC Evolutionary Biology·Jennifer AntonidesJ Andrew DeWoody
Jan 9, 2019·Frontiers in Cellular and Infection Microbiology·Hongkuan DengMuriel Vayssier-Taussat
Feb 16, 2021·Frontiers in Endocrinology·Christopher R Shepard
Apr 14, 2021·Genetics and Molecular Biology·Tatiana Maia de OliveiraMaria Paula Cruz Schneider
Dec 22, 2020·Cytokine & Growth Factor Reviews·Marina DukhinovaAnna Shtro
Jun 2, 2021·Journal of Evolutionary Biology·Erwan QuéméréNathalie Charbonnel
Oct 3, 2021·Journal of Molecular Biology·Asen Daskalov, N Louise Glass

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Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

FastQC
DnaSP
irelr package for R
R
gmap
Freebayes
Python script
mem
Bedtools
Arlequin

Related Concepts

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Bartonellosis

Bartonellosis is an infection caused by bacteria in the genus Bartonella and can present as a variety of diseases depending on the organism involved. While asymptomatic infection has been reported, immunocompromised individuals are more susceptible to severe infection. Find the latest research on bartonellosis here.