Sep 29, 2020

Environment-dependent behavioral traits and experiential factors shape addiction vulnerability

BioRxiv : the Preprint Server for Biology
M. FouyssacDavid Belin

Abstract

The transition from controlled drug use to drug addiction depends on an interaction between a vulnerable individual, their environment and a drug. However, the determining factors of this interaction are not well understood. We show in rats that the environment influences the acquisition of drug intake through its effect on behavioral markers of resilience to addiction. In contrast, the development of both compulsive cocaine and alcohol intake is facilitated by the experiential factors associated with the initiation of drug taking in a negative, deprived state occasioned by the contrast between enriched housing conditions and a relatively impoverished drug taking setting. Similarly, the acquisition of alcohol drinking as a coping strategy is associated with the development of compulsive intake. These data demonstrate that addiction vulnerability depends significantly on environmentally determined experiential factors.

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Genetic Drift
Study
Carbohydrate nutrients
Diet
Genome
Genes
Candidate Disease Gene
GEA 857
Genomics
Adaptation

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Related Papers

Sheng li ke xue jin zhan [Progress in physiology]
Hao-Ran WangJi-Sheng Han
Reviews in the Neurosciences
Heidi M B Lesscher, Louk J M J Vanderschuren
© 2020 Meta ULC. All rights reserved