Sep 29, 2020

Environment-dependent behavioral traits and experiential factors shape addiction vulnerability

BioRxiv : the Preprint Server for Biology
M. FouyssacDavid Belin


The transition from controlled drug use to drug addiction depends on an interaction between a vulnerable individual, their environment and a drug. However, the determining factors of this interaction are not well understood. We show in rats that the environment influences the acquisition of drug intake through its effect on behavioral markers of resilience to addiction. In contrast, the development of both compulsive cocaine and alcohol intake is facilitated by the experiential factors associated with the initiation of drug taking in a negative, deprived state occasioned by the contrast between enriched housing conditions and a relatively impoverished drug taking setting. Similarly, the acquisition of alcohol drinking as a coping strategy is associated with the development of compulsive intake. These data demonstrate that addiction vulnerability depends significantly on environmentally determined experiential factors.

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Mentioned in this Paper

Genetic Drift
Carbohydrate nutrients
Candidate Disease Gene
GEA 857

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