PMID: 8942871Nov 1, 1996Paper

Signet ring cell carcinoma of the eccrine sweat glands in the eyelid

Ophthalmology
G WollensakN Böhm

Abstract

Signet ring cell carcinoma of the eyelid is a rare variant of eccrine sweat gland carcinoma and has been reported previously in only five patients. The authors report the clinical findings of a 55-year-old man with a signet ring cell carcinoma in the left eyelid as well as a clinical follow-up of 4.5 years. Several biopsies and the exenteration specimen were analyzed by routine light microscopy, electron microscopy, and comprehensive immunohistochemical stains on paraffin sections. Histologically, the tumor was shown to be a rare type of eccrine sweat gland carcinoma with signet ring cells and Indian file growth pattern reminiscent of invasive lobular carcinoma of the breast. Estrogen and progesterone receptors were identified immunohistochemically. On electron microscopy, intracytoplasmic pseudolumina with microvilli were positive for anti-human milk fat globulin and the lectin peanut agglutinin. Clinically, the tumor followed a malignant course with orbital invasion and lymph node metastases. Histologic recognition of this variant of eccrine sweat gland carcinoma is important because of its aggressive and malignant behavior and the wide range of differential diagnoses. Primarily, metastatic mammary carcinoma must be excluded....Continue Reading

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Citations

Jul 10, 2003·Survey of Ophthalmology·Subramanian KrishnakumarJyotirmay Biswas
Feb 23, 1999·The American Journal of Dermatopathology·Y KunoT Kanzaki
Aug 2, 2001·The American Journal of Dermatopathology·C González-LoisF López-Ríos
Aug 14, 2012·The American Journal of Dermatopathology·Jantima TanboonPanitee Luemsamran
Mar 30, 2010·International Ophthalmology Clinics·Jonathan W Kim, Diana K Lee
Dec 5, 2012·Journal of Cutaneous Pathology·Diana DroubiPaul N Bogner
Sep 26, 2013·Orbit·Jennifer S L TanThomas G Hardy
May 2, 2016·Brazilian Journal of Otorhinolaryngology·Malgorzata Seredyka-BurdukAndrzej Kopczynski
Feb 26, 2011·Korean Journal of Ophthalmology : KJO·Young Min KimDong-Eun Oh
Jul 9, 2016·The American Journal of Dermatopathology·Claudia BernárdezLuis Requena
Mar 15, 2016·Ophthalmic Plastic and Reconstructive Surgery·Meredith S BakerErin M Shriver
Apr 10, 2008·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Anouck Leuba MortensenJan Ulrik Prause
May 3, 2020·Journal of Cutaneous Pathology·Shyam S RaghavanRyanne A Brown
Jul 28, 2006·Clinical and Experimental Dermatology·B SwinsonN Kalavrezos
Sep 29, 2018·Clinical and Experimental Dermatology·A OnoeT Ochiai
Oct 3, 2020·Ocular Oncology and Pathology·Frederick A JakobiecAnna M Stagner

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