Signet ring-like cells in pituitary adenoma

Pathology, Research and Practice
Kemal DenizFahrettin Keleştimur

Abstract

We describe a case of non-functioning pituitary adenoma in a 35-year-old woman with a prior history of fertility problems. The patient had received clomiphen citrate and human chorionic gonadotrophin for 3 years. Histological examination of the tumor revealed signet ring-like cell areas admixed with minor conventional round-polygonal neoplastic cells. The two populations of tumor cells showed strong immunoreactivity for chromogranin and synaptophysin. The clinicopathologic features and diagnostic difficulties of this rare entity are discussed.

References

Jun 1, 1965·Endocrinologia Japonica·F Yoshimura, K Harumiya
Jan 1, 1994·Current Therapy in Endocrinology and Metabolism·M H Samuels
Dec 31, 1997·Archives of Histology and Cytology·T JeziorowskiD Grube
Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·John KomninosNicolas C Thalassinos

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Citations

Jul 19, 2008·Acta Histochemica Et Cytochemica·Noboru EgashiraRobert Y Osamura
Dec 4, 2009·Human Pathology·Sarah E MartinEyas M Hattab
Mar 20, 2018·Applied Immunohistochemistry & Molecular Morphology : AIMM·Levent TrabzonluSavas Ceylan
Jan 11, 2017·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Chiara CaporaliniGian Luigi Taddei
Feb 12, 2020·Applied Immunohistochemistry & Molecular Morphology : AIMM·Levent TrabzonluSavas Ceylan

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