PMID: 9550318Apr 29, 1998Paper

Signet-ring squamous cell carcinoma: a case report

Journal of Cutaneous Pathology
E McKinleyT Bocklage

Abstract

A-50-year-old Hispanic man presented to the dermatology clinic with a 0.6-cm eroded, erythematous, scaly plaque on the left side of his neck. On shave biopsy, the lesion was composed of intra-epidermal and invasive dermal cells characterized by a signet-ring appearance. One area suggestive of typical squamous cell carcinoma prompted the inclusion of that entity in the differential diagnosis. Mucicarmine stains were negative, while the extra-vacuolar cytoplasm focally reacted with periodic acid-Schiff staining, the positive reaction for which was abolished by diastase, consistent with glycogen. Malignant cells expressed keratins by reacting to antibodies, Mak6, AE1/AE3, Ker 903, and CAM5.2. Additionally, weak reactivity occurred with antibodies to CEA and EMA. Tumor cells did not express S-100, HM-B45, Leu M1, or actin. By ultrastructural examination, the large vacuoles corresponded to markedly dilated endoplasmic reticulum. A diagnosis of signet-ring squamous cell carcinoma, a rare form of cutaneous squamous cell carcinoma which has been described in only one case report in the last 10 years, was made. Immunohistochemical staining provided information useful in differentiating this lesion from other clear cell and signet-ring c...Continue Reading

References

Jun 1, 1978·The American Journal of Surgical Pathology·H KimH Rappaport
Aug 1, 1991·The Journal of Dermatologic Surgery and Oncology·L RequenaE Sánchez Yus
Jun 1, 1988·Journal of Cutaneous Pathology·R E Cohen, M T Zaim
Apr 1, 1989·American Journal of Clinical Pathology·S F Cramer, L M Heggeness
Oct 1, 1985·Diagnostic Cytopathology·G A Herrera, J A Wilkerson
Aug 1, 1972·Cancer·K Hashimoto, G F Bale
Oct 1, 1972·Cancer·M Ranchod
Aug 1, 1981·Journal of Clinical Pathology·M HarrisG Read
Aug 1, 1993·Journal of Cutaneous Pathology·R J BarrD F Fretzin

❮ Previous
Next ❯

Citations

Aug 31, 2010·The American Journal of Dermatopathology·José Fernando Val-BernalMaría Francisca Garijo
Apr 20, 2012·The American Journal of Dermatopathology·Asok Biswas, Meera Mahalingam
Jun 27, 2008·The American Journal of Surgical Pathology·Thomas M Ulbright, Robert H Young
Sep 16, 2009·Journal of Cutaneous Pathology·Dina El DemellawySalem Alowami
Feb 10, 2006·Journal of Cutaneous Pathology·David S CassarinoRonald J Barr
Aug 3, 2001·Cancer Control : Journal of the Moffitt Cancer Center·M H RinkerL F Glass
Jul 18, 2020·Proceedings·Sarah K FindeisAtin Agarwal
Apr 25, 2006·Journal of Cutaneous Pathology·David S CassarinoRonald J Barr
Aug 2, 2003·The Veterinary Record·A Espinosa de los MonterosF Rodríguez
Nov 6, 2007·Archives of Pathology & Laboratory Medicine·Iskander H Chaudhry, Artur Zembowicz
Mar 8, 2006·Archives of Pathology & Laboratory Medicine·Alan D ProiaJohn J Michon
Feb 20, 2021·The American Journal of Dermatopathology·Tien Anh N TranKonstantinos Linos
Aug 20, 2021·The American Journal of Dermatopathology·Pedro ZaballosLuis Requena

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Related Papers

Journal of the European Academy of Dermatology and Venereology : JEADV
H Baloglu, B Dogan
Journal of Cutaneous Pathology
N U AhmedM Ichihashi
© 2022 Meta ULC. All rights reserved