Significance and Diagnostic Accuracy of Early S100B Serum Concentration after Aneurysmal Subarachnoid Hemorrhage

Journal of Clinical Medicine
Baptiste BalançaFrédéric Dailler

Abstract

Early brain injuries (EBI) are one of the most important causes of morbidity and mortality after subarachnoid hemorrhage. At admission, a third of patients are unconscious (spontaneously or sedated) and EBI consequences are not evaluable. To date, it is unclear who will still be comatose (with severe EBI) and who will recover (with less severe EBI) once the aneurysm is treated and sedation withdrawn. The objective of the present study was to determine the diagnostic accuracy of S100B levels at hospital admission to identify patients with severe neurological consequences of EBI. Patients were consecutively included in this prospective blinded observational study. A motor component of the Glasgow coma score under 6 on day 3 was used to define patients with severe neurological consequences of EBI. A total of 81 patients were included: 25 patients were unconscious at admission, 68 were treated by coiling. On day 3, 12 patients had severe consequences of EBI. A maximal S100B value between admission and day 1 had an area under the receiver operating characteristic curve (AUC) of 86.7% to predict severe EBI consequences. In patients with impaired consciousness at admission, the AUC was 88.2%. Early S100B seems to have a good diagnosti...Continue Reading

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Citations

Jan 10, 2021·Journal of Clinical Medicine·Jaroslaw KedzioraBarbara Adamik
Mar 7, 2021·International Journal of Molecular Sciences·Baptiste BalançaAnne-Claire Lukaszewicz

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Methods Mentioned

BETA
sedation

Clinical Trials Mentioned

NCT02890004

Software Mentioned

IntelliSpace Critical Care and Anesthesia
R Foundation for Statistical Computing
R
pROC

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