Significance of administration of fat emulsion: hepatic changes in infant rats receiving total parenteral nutrition with and without fat

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
M OshitaS Tashiro

Abstract

Total parenteral nutrition (TPN) is associated with cholestasis and hepatic steatosis, which can be lethal in infants who cannot be fed orally. The present animal study focused on the metabolic complications in the liver that may occur due to the excessive administration of fat-free TPN. Thirty infant (3-week-old) male SD rats weighing 60-70 g were randomly allocated to five groups (n = 6): the OD group received an oral diet, the FT group received an oral diet and was fasted overnight on the last day of experiment before sacrifice, the 0% fat group received TPN without fat, the 20% fat group received TPN with 20% of calories from fat emulsion, and the 40% fat group received TPN with 40% of calories from fat emulsion. All TPN regimens were isocaloric, isonitrogenic, and administered for 4 days. In the 0% fat group, plasma levels of liver enzymes were significantly higher than in the other groups. Pathological examination showed hepatomegaly and severe fatty changes without cholestasis in the 0% fat group. The results of this study in infant rats indicate the importance of including fat in the TPN regimen in order to prevent the abnormal hepatic changes associated with the excessive administration of fat-free TPN.

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Citations

Aug 20, 2008·Antioxidants & Redox Signaling·Noga Budick-HarmelinOren Tirosh
Jul 6, 2005·Biological & Pharmaceutical Bulletin·Masuhiro NishimuraShinsaku Naito
May 3, 2006·Biological & Pharmaceutical Bulletin·Masuhiro NishimuraAiko Yamauchi
Jan 17, 2012·Journal of Pediatric Surgery·Shawn J RangelUNKNOWN 2011 American Pediatric Surgical Association Outcomes and Clinical Trials Committee
Nov 3, 2010·Journal of the American Dietetic Association·Catherine J KleinLouis Scavo
Apr 3, 2008·The Journal of Pharmacy and Pharmacology·Hiroko OhkawaKen-ichi Miyamoto
Jun 13, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F W GuglielmiA Francavilla
Jul 31, 2013·JPEN. Journal of Parenteral and Enteral Nutrition·Keizo FukushimaNobuyuki Sugioka
Apr 24, 2010·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Michael D RollinsLinda S Book
Apr 14, 2010·Current Opinion in Organ Transplantation·M Petrea Cober, Daniel H Teitelbaum
Apr 12, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Kathrin Krohn, Berthold Koletzko
Oct 19, 2013·Experimental and Therapeutic Medicine·Rong LiBin Jin

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