Significance of androgen receptor and CD10 expression in cutaneous basal cell carcinoma and trichoepithelioma

Oncology Letters
Hesna M AstarciHuseyin Ustun

Abstract

Differential diagnosis of trichoepithelioma (TE) and basal cell carcinoma (BCC) on the basis of clinical symptoms and laboratory investigations may be difficult in certain patients. The aim of the present study was to compare cluster of differentiation 10 (CD10) and androgen receptor (AR) expression patterns in BCC and TE, to investigate the predictive power of these proteins as markers of the two conditions. A total of 39 cases of BCC and 15 cases of TE were retrieved from the pathology department archives. AR and CD10 immunohistochemistry was performed on all of the specimens; 23 BCC cases displayed focal nuclear AR staining, however, none of the cases demonstrated diffuse nuclear staining and 16 BCC cases were negative for AR staining. Stromal CD10 staining was more common in TE cases than in BCC cases, and peripheral CD10 staining was more common in BCC cases than in TE cases. AR immunostaining of the BCC samples typically appeared as scattered clusters and individual cells. In addition, AR and CD10 staining exhibited varying staining intensities within each samples. Incisional punch biopsy specimens have the potential to present false-negative results. Therefore, AR and CD10 staining of total excision biopsies provides a m...Continue Reading

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Citations

Oct 27, 2017·Archives of Pathology & Laboratory Medicine·Lauren M StanoszekPaul W Harms
Jun 26, 2018·International Journal of Surgical Pathology·Cem LeblebiciGülben Erdem Huq
Apr 21, 2020·The American Journal of Dermatopathology·Ashley E BrownSylvia Hsu
Aug 19, 2020·The American Journal of Dermatopathology·Osward Y CarrasquilloSheila M Valentín-Nogueras

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Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS

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