PMID: 9008306Dec 1, 1996Paper

Significance of antibodies to streptococcal M protein in psoriatic arthritis and their association with HLA-A*0207

Tissue Antigens
M MutoC Asagami

Abstract

Psoriatic arthritis (PA) is an immune disease associated with HLA-A2 in the Japanese population. To investigate mechanisms the association between HLA-A2 and PA, we examined in vivo immune responsiveness to Streptococcus pyogenes. Recombinant M proteins for the subtype specific N-terminal half (AB region) and conserved C-terminal half (C region) were produced separately. IgG antibody level against each region was measured by ELISA in 31 PA patients, 88 patients with psoriasis vulgaris, 6 patients with rheumatoid arthritis and 77 healthy controls. We found that IgG antibody levels against the C region were markedly higher in the PA patient group than in the other disease groups or controls. Further, IgG antibody levels were higher in PA patients with spondylitis and polyarticular arthritis than in PA patients with rheumatoid-like arthritis and arthritis mutilans. In contrast, no significant difference in the IgG antibody levels against the AB region was observed among the tested groups. HLA-A2 DNA typing showed that HLA-A*0207 was associated with PA (RR = 17.6; pcorr < 0.01) and the IgG antibody responses to the C region correlated well with the presence of HLA-A*0207. These results suggest that streptococcal infection may be in...Continue Reading

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Citations

Jan 5, 2002·Arthritis and Rheumatism·L StaffordO Fitzgerald
Jul 24, 2008·Archives of Dermatological Research·Limor NaharyItai Benhar
Mar 22, 2012·Immunologic Research·Kenneth Yuanxiang ChenEe Chee Ren
Apr 15, 2003·Human Immunology·Umapathy ShankarkumarDipika Mohanty
Feb 7, 2002·Annals of the Rheumatic Diseases·T HöhlerE Märker-Hermann
Sep 21, 2001·Current Rheumatology Reports·P Costello, O FitzGerald
Nov 17, 2005·Rheumatic Diseases Clinics of North America·David Kane, Sanjay Pathare
May 1, 2004·International Journal of Dermatology·Mario E Cancino-DíazEthel García-Latorre
Jan 1, 2005·Journal of the American Academy of Dermatology·Philip Mease, Bernard S Goffe
Sep 29, 2004·Dermatologic Clinics·Eric M Ruderman, Siddharth Tambar
Nov 11, 2017·Rheumatology International·Telma Thrastardottir, Thorvardur Jon Love
Apr 5, 2003·Archives of Dermatological Research·Masahiko MutoHideoki Ogawa
Feb 12, 2021·Seminars in Immunopathology·Katharine Lu YangSergei B Koralov

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