PMID: 9187561Apr 1, 1997Paper

Significance of antigen-specific T cell clones in collagen diseases: analyses with a novel T cell clonality evaluation system

Internal Medicine
K Yamamoto

Abstract

The involvement of antigen-specific T cells in the pathogenesis of collagen diseases is still controversial. The final stages of collagen diseases are usually characterized by the dominance of inflammation. Therefore, antigen non-specific factors, such as inflammatory cytokines, probably play an important role in this process. On the other hand, the methods available to analyze the antigen-specific aspects of the immune response are still limited. Here we review our novel system of T cell clonality analysis based on the idea that activated antigen-specific T cells should form accumulating clones among the lymphocyte population. Using this method, dynamic changes of clonal accumulation of T cells could be evaluated during antigenic stimulation in vivo and in vitro. The significance of antigen-specific T cell clones in collagen diseases is discussed using data obtained from patients with rheumatoid arthritis and systemic lupus erythematosus.

Citations

May 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J H LaiS H Han

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