Significance of antineutrophil cytoplasmic antibody in adult patients with Henoch-Schönlein purpura presenting mainly with gastrointestinal symptoms.

World Journal of Gastroenterology : WJG
Yan ZhangQin Ouyang

Abstract

To test the clinical significance of antineutrophil cytoplasmic antibody (ANCA) in evaluation of adult Henoch-Schonlein purpura (HSP) patients presenting mainly with abdominal symptoms. Twenty-eight consecutive HSP patients who presented predominantly with abdominal symptoms were enrolled in this study. Control subjects included 27 age- and sex-matched patients with peptic ulcer disease, colon cancer, acute gastroenteritis, irritable bowel syndrome and colonic polyps. ANCA was measured by indirect immunofluorescence (IIF) in all patients, and follow-up ELISA was performed in patients with positive IIF tests. ANCA was detected in 9 HSP patients by IIF (2 were positive for c-ANCA and 7 were positive for p-ANCA). No ANCA was found in the control group. The sensitivity and specificity of a positive ANCA test (either c- or p-ANCA) were 32.1% and 100% respectively. Only one out of the 9 patients with positive ANCA by IIF had positive ANCA by ELISA and the antigen was myeloperoxidase (MPO). The patients positive for ANCA had higher HSP clinical scores, and were more likely to have renal function impairment. Patients with late purpura development were also associated with more severe clinical manifestations. A positive ANCA test is ass...Continue Reading

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Citations

Apr 14, 2016·Laboratory Medicine·Zheng CaoAnthony O Okorodudu
Nov 10, 2016·Anais Brasileiros De Dermatologia·Pedro de Freitas Silva TorracaGünter Hans
Jul 29, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·William ChotasAsad Tolaymat
May 15, 2013·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Tuan BuiBasil M Fathalla
Nov 24, 2020·Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders·Vadood Javadi ParvanehReza Shiari

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