Significance of body weight change during fertility-sparing progestin therapy in young women with early endometrial cancer

Gynecologic Oncology
Jeong-Yeol ParkJoo-Hyun Nam

Abstract

To evaluate the influence of body weight change during fertility-sparing progestin therapy on oncologic and reproductive outcomes in young women with early-stage endometrial cancer who did not complete child bearing. This multicenter, retrospective study included 154 young patients with well-differentiated, endometrium-confined endometrioid endometrial adenocarcinoma on magnetic resonance imaging who received fertility-sparing progestin therapy. The mean body weight and body mass index (BMI) at baseline and progestin therapy completion was 65.3±16.2 and 66.5±15.9kg (P=0.044), respectively, and 25.51±5.99 and 25.99±5.94kg/m(2) (P=0.034), respectively. During progestin therapy, 51 (33.1%), 29 (18.8%), and 74 patients (48.1%) had weight loss, no weight change, and weight gain, respectively, of which 11 (7.1%) had 10% weight loss and 30 (19.5%) had 10% weight gain. A pretreatment BMI of ≥25kg/m(2) was significantly associated with a lower complete response rate to progestin therapy (P=0.003) and a high recurrence rate (P=0.033). A posttreatment BMI of ≥25kg/m(2) was also a significant factor for high recurrence rate (P=0.049). However, weight change during therapy was not significantly associated with complete response or recurrenc...Continue Reading

Citations

Jul 12, 2018·European Radiology·Stephanie NougaretRosemarie Forstner
Oct 16, 2018·Minerva ginecologica·Stella CapriglioneSalvatore Lopez
Jul 22, 2020·Obstetrics & Gynecology Science·Andreas ObermairMonika Janda
Apr 4, 2021·Journal of Clinical Medicine·Krzysztof GałczyńskiAndrzej Semczuk

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