Abstract
Central perivenulitis (CP) encompasses dropout of zone 3 hepatocytes, red blood cell extravasation, and perivenular mononuclear inflammation. In the liver transplant setting, CP can occur in isolation or it can occur in association with portal-based disease such as acute cellular rejection (PB-ACR). Some CP is also thought to be a manifestation of chronic rejection, particularly when accompanied by zone 3 fibrosis. Prior studies of CP in pediatric liver allografts have been hampered by lack of protocol biopsies and low rates of histologic follow-up. We studied 62 consecutive liver allografts from 55 pediatric patients (age: < or =18 y) who underwent transplant from the years 1995 to 2007. Forty-nine allografts (79%) had > or =1 year of histologic follow-up, 32 (52%) > or =3 years, and 24 (39%) > or =5 years. We reviewed a total of 445 allograft biopsies (mean: 7.2 per allograft) obtained at 2 days to 11 years; 213 (48%) of these were protocol biopsies. Seven explanted livers that were removed during the course of retransplantation for graft failure in this group were also reviewed. All specimens were scored for the following features: (1) CP (mild, moderate, and severe), (2) portal ACR (mild, moderate, and severe), (3) zone 3 f...Continue Reading
References
Jun 1, 1990·Human Pathology·J LudwigS B Moore
Jul 1, 1988·Human Pathology·R A RayR W Busuttil
Nov 27, 1995·Transplantation·A C AnandJ M Neuberger
Sep 1, 1994·Journal of Hepatology·R GómezV Maffettone
Jun 1, 1993·Human Pathology·R Rubin, S J Muñoz
Mar 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Jul 27, 1997·Transplantation·A C TsamandasR G Lee
Sep 1, 1995·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·B TurlinB Portmann
Apr 1, 1998·Transplantation·K J AllenP F Whitington
Mar 8, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A DemetrisH Yamabe
May 8, 2000·Transplantation·E J PesonenH Repo
Jun 3, 2000·Transplantation·Y NakazawaA D Clouston
Nov 28, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y NakazawaA D Clouston
May 9, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A M KrasinskasE E Furth
Jan 17, 2002·Transplantation·Lorenzo D'AntigaGiorgina Mieli-Vergani
Feb 1, 2002·Transplantation·Annette S H GouwSibrand Poppema
Feb 1, 2002·Transplantation·Florence LacailleOlivier Goulet
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Desley A H Neil, Stefan G Hubscher
Apr 30, 2002·Human Pathology·Urmila KhettryFredric D Gordon
Oct 5, 2002·Transplantation·Steven R MartinFernando Alvarez
Jan 7, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Lydia M Petrovic
Apr 17, 2003·Transplantation·Ashok JainJorge Reyes
Mar 9, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Michael O LovellFrancis E Sharkey
Mar 30, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ziad HassounLydia M Petrovic
Dec 31, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Shikha S SundaramEstella M Alonso
Jul 28, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anthony J DemetrisFunda Yilmaz
Apr 25, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Alyssa M KrasinskasSusan C Abraham
Citations
Feb 1, 2011·Der Pathologe·U DrebberH P Dienes
Jun 14, 2012·Advances in Anatomic Pathology·Nadia OvchinskyJoel E Lavine
Feb 28, 2013·Transplantation·Prem H ThurairajahJames Neuberger
May 2, 2014·World Journal of Gastroenterology : WJG·Odile WarlingEdouard Louis
Oct 31, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·John Bucuvalas
Oct 31, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Stefan Hübscher
Aug 31, 2012·Pediatric Transplantation·Hiroyuki YamadaKeiichi Ozono
Mar 2, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ananya PongpaibulCharles R Lassman
Aug 14, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C VenturiR Reding
Aug 21, 2010·Transplant International : Official Journal of the European Society for Organ Transplantation·Desley A H Neil, Stefan G Hübscher
Jan 29, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R Todd StravitzUNKNOWN Acute Liver Failure Study Group
Dec 5, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Taizen UrahashiNoriki Okada
Jun 18, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C VenturiR Reding
Aug 13, 2013·Journal of Hepatology·Louise BarbierJean Hardwigsen
Mar 18, 2009·Human Pathology·Jay H Lefkowitch
Oct 15, 2014·Pediatric Transplantation·Takanobu ShigetaMureo Kasahara
Mar 24, 2011·Journal of Hepatology·Stefan G Hübscher
Apr 20, 2016·Pediatric Transplantation·Yohei YamadaTatsuo Kuroda
Jun 9, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A J DemetrisY Zen
Oct 20, 2012·Expert Review of Clinical Immunology·Shishir ShettyStefan G Hubscher
Apr 26, 2020·Pediatric Transplantation·Masahiro TakedaMureo Kasahara
Jun 20, 2017·Pediatric Transplantation·Marjolein BaasRené Scheenstra
Apr 25, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hiroto EgawaShinji Uemoto
Dec 1, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Iván A GonzálezMai He
Nov 17, 2020·Frontiers in Immunology·Yue WuQiang Xia