PMID: 3767463Sep 1, 1986Paper

Significance of connective tissue proliferation in the breakdown of cartilage: a novel in vivo model

Annals of the Rheumatic Diseases
F B De BritoD A Willoughby

Abstract

The implantation of homologous femoral head cartilage in subcutaneous tissues of random bred Wistar rats results in both subchondral and articular surfaces becoming overlaid by an adherent granulation tissue comprising predominantly fibroblast-like cells. The response of the tissue to cartilage encapsulated with cotton fibres was also similar but erosions, mainly subchondral, were more evident and proteoglycan loss markedly greater. The connective tissue response to cotton was the progressive formation of a foreign body granuloma comprising mononuclear cells, multinucleated giant cells, and fibroblasts with very few polymorphonuclear leucocytes.

References

Mar 1, 1979·Biochemical Pharmacology·P C FreemanD K Watkins
May 1, 1972·Annals of the Rheumatic Diseases·A L Macafee
Jan 1, 1972·Journal of Clinical Pathology·A D Pearse, D L Gardner
Jan 1, 1973·Advances in Immunology·N J Zvaifler
Jan 1, 1972·Scandinavian Journal of Rheumatology·P A Drablos
Jan 1, 1982·Connective Tissue Research·R W FarndaleA J Barrett
Dec 1, 1983·The Journal of Pathology·A D SedgwickD A Willoughby
Jan 1, 1984·The Journal of Pathology·Y M SinD A Willoughby

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Citations

Jul 1, 1993·Arthritis and Rheumatism·J A da SilvaD A Willoughby
Aug 1, 1987·Agents and Actions·F B De BritoD A Willoughby
Mar 1, 1991·Annals of the Rheumatic Diseases·C L Chander, T D Spector
Nov 2, 2005·Inflammopharmacology·K D Rainsford
Mar 1, 1988·The Journal of Pharmacy and Pharmacology·K M BottomleyA Steward

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