Significance of cytoplasmic cyclin D1 expression in oral oncogenesis

Oral Diseases
P Ramos-GarcíaM Á González-Moles

Abstract

To examine cytoplasmic cyclin D1 expression levels in oral carcinogenesis and evaluate their possible oncogenic significance and their clinicopathological and prognostic implications. Immunohistochemical analysis of 69 oral squamous cell carcinomas (OSCCs) was performed, revealing 23 with cytoplasmic cyclin D1 expression. We analyzed the association of the percentage of cyclin D1-positive cells and the intensity of expression with TNM classification, tumor stage, differentiation degree, cell morphology, and Ki-67 expression. Cytoplasmic cyclin D1 expression was associated with advanced tumor stage, poor differentiation, elevated Ki-67 expression, and the presence of invasive cell morphology, indicators of a poor prognosis. An association was observed between nuclear and cytoplasmic expressions of cyclin D1. Cytoplasmic expression of cyclin D1 appears to possess functions related to increased cell migration and invasion in OSCC.

References

Sep 24, 2004·Physiological Reviews·Michael C Brown, Christopher E Turner
Nov 17, 2004·Genes & Development·Charles J Sherr, James M Roberts
Jun 3, 2005·Thyroid : Official Journal of the American Thyroid Association·Cheryl A PickettMary P Bronner
May 18, 2006·Molecular and Cellular Biology·Zhiping LiRichard G Pestell
Mar 22, 2007·British Journal of Cancer·C E S ComstockK E Knudsen
Oct 3, 2007·Nature Cell Biology·Ekta Seth Chhabra, Henry N Higgs
Dec 16, 2016·Oral Diseases·P Ramos-GarcíaM A González-Moles
Aug 12, 2017·Oral Oncology·Pablo Ramos-GarcíaMiguel Ángel González-Moles

❮ Previous
Next ❯

Citations

Mar 10, 2020·Pigment Cell & Melanoma Research·Lucia González-RuizPablo Ramos-García
Jan 15, 2021·Journal of Immunoassay & Immunochemistry·Sarra Ben RejebRaoudha Doghri
Jan 30, 2020·Oral Diseases·Pablo Ramos-GarciaMiguel Angel Gonzalez-Moles

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology
Jin-Song XingXin-Rong Nan
Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban
Sanbao TangBin Zhou
© 2022 Meta ULC. All rights reserved