Abstract
To examine cytoplasmic cyclin D1 expression levels in oral carcinogenesis and evaluate their possible oncogenic significance and their clinicopathological and prognostic implications. Immunohistochemical analysis of 69 oral squamous cell carcinomas (OSCCs) was performed, revealing 23 with cytoplasmic cyclin D1 expression. We analyzed the association of the percentage of cyclin D1-positive cells and the intensity of expression with TNM classification, tumor stage, differentiation degree, cell morphology, and Ki-67 expression. Cytoplasmic cyclin D1 expression was associated with advanced tumor stage, poor differentiation, elevated Ki-67 expression, and the presence of invasive cell morphology, indicators of a poor prognosis. An association was observed between nuclear and cytoplasmic expressions of cyclin D1. Cytoplasmic expression of cyclin D1 appears to possess functions related to increased cell migration and invasion in OSCC.
References
Aug 19, 1999·Journal of Gastroenterology·Y SatoK Imai
Dec 10, 1999·British Journal of Cancer·K K DharP R Hoban
Feb 13, 2001·British Journal of Cancer·V M TutJ K Mellon
Aug 9, 2001·International Journal of Cancer. Journal International Du Cancer·T A HollandP R Hoban
Jul 9, 2004·Pathology, Research and Practice·Banu LebeFunda Obuz
Sep 24, 2004·Physiological Reviews·Michael C Brown, Christopher E Turner
Nov 17, 2004·Genes & Development·Charles J Sherr, James M Roberts
Jun 3, 2005·Thyroid : Official Journal of the American Thyroid Association·Cheryl A PickettMary P Bronner
May 18, 2006·Molecular and Cellular Biology·Zhiping LiRichard G Pestell
Mar 22, 2007·British Journal of Cancer·C E S ComstockK E Knudsen
Oct 3, 2007·Nature Cell Biology·Ekta Seth Chhabra, Henry N Higgs
Feb 25, 2010·Cancer Research·Zhijiu ZhongAndrew A Quong
May 18, 2016·Nature Communications·Noel P FustéEloi Garí
Dec 16, 2016·Oral Diseases·P Ramos-GarcíaM A González-Moles
Aug 12, 2017·Oral Oncology·Pablo Ramos-GarcíaMiguel Ángel González-Moles
Citations
Jul 23, 2020·Journal of Clinical Laboratory Analysis·Yijun LiuWenling Zhang
Jun 12, 2019·Cancer Medicine·Qing-Shui WangYao Lin
Jun 12, 2019·Head & Neck·Pablo Ramos-GarcíaIsabel Ruiz-Ávila
Aug 28, 2020·Cancers·Miguel Ángel González-MolesPablo Ramos-García
Mar 10, 2020·Pigment Cell & Melanoma Research·Lucia González-RuizPablo Ramos-García
Jan 15, 2021·Journal of Immunoassay & Immunochemistry·Sarra Ben RejebRaoudha Doghri
Jan 30, 2020·Oral Diseases·Pablo Ramos-GarciaMiguel Angel Gonzalez-Moles
Apr 4, 2021·Cancers·Lucía González-RuizPablo Ramos-García