PMID: 15218973Jun 29, 2004Paper

Significance of decreased plasma D-dimer levels following lipopolysaccharide-induced disseminated intravascular coagulation in rats

International Journal of Hematology
H AsakuraS Nakao

Abstract

Plasma D-dimer (DD) is considered to be one of the most useful markers in the diagnosis and assessment of disseminated intravascular coagulation (DIC). The present study was performed to clarify the role of DD in a rat model of lipopolysaccharide (LPS)-induced DIC in which low-molecular-weight heparin (LMWH) and tranexamic acid (TA) were used. We investigated whether a relationship exists between plasma DD levels and severity of DIC. Experimental DIC was induced in rats by a sustained 4-hour infusion of 30 mg/kg LPS administered via the tail vein (LPS group). Rats received either LPS alone (LPS group) or LPS combined with 200 U/kg LMWH (LPS+LMWH group) or 50 mg/kg TA (LPS+TA group) from -30 minutes to 4 hours. Blood was drawn from each rat at 4, 8, and 12 hours. Plasma levels of thrombin-antithrombin complex (TAT) and creatinine were suppressed in the LPS+LMWH group, and less glomerular fibrin deposition was observed compared with the LPS group. On the other hand, an increased level of creatinine and increased glomerular fibrin deposition were observed in the LPS+TA group compared with the LPS group. LMWH demonstrated a protective effect against LPS-induced DIC, resulting in increased survival at 12 hours, whereas TA had the op...Continue Reading

References

Sep 1, 1988·British Journal of Haematology·G AvvisatiF Mandelli
Mar 1, 1989·American Journal of Clinical Pathology·J M CarrJ McDonagh
Oct 1, 1994·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·H AsakuraT Matsuda
Feb 1, 1993·American Journal of Hematology·H WadaK Deguchi
Mar 27, 1998·Seminars in Thrombosis and Hemostasis·R L Bick
Aug 19, 1999·The New England Journal of Medicine·M Levi, H Ten Cate
Mar 29, 2002·Immunological Reviews·K Okajima
Apr 16, 2003·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Hidesaku AsakuraShinji Nakao

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