PMID: 9446193Jan 31, 1998Paper

Significance of delayed eosinophilic apoptosis in chronic allergic inflammations

Schweizerische medizinische Wochenschrift
H-U Simon

Abstract

Eosinophils are potent inflammatory cells involved in allergic reactions. Recent studies suggest that delayed eosinophil apoptosis is a pathogenic event for the accumulation of these cells in chronic eosinophilic inflammation. Therefore, it is important to study the mechanisms which regulate eosinophil apoptosis. Such knowledge may help to identify useful targets for the development of new drugs. Here we review recent progress in our understanding of the processes regulating eosinophil apoptosis.

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis