Significance of detecting insulin-like growth factor binding protein-1 in cervicovaginal secretions: comparison with nitrazine test and amniotic fluid volume assessment

Acta Obstetricia Et Gynecologica Scandinavica
Evrim Erdemoglu, Tamer Mungan

Abstract

The diagnosis of premature rupture of membranes (PROM) is sometimes challenging, and common diagnostic tests are of limited value in the diagnosis. We aimed to study the accuracy of detecting insulin-like growth factor binding protein-1 (IGFBP-1) in vaginal fluid by a rapid dipstick method in comparison with the nitrazine test and amniotic fluid index (AFI) and we studied the predictivity of these methods on the latency of pregnancy in patients with suspected PROM. One hundred and fifty-one patients (36 definite PROM, 35 no PROM and 80 suspected PROM) at 20-42 weeks' gestation were included in the study. Patients with preterm labor and PROM, patients at <20 gestational weeks, and those with multiple pregnancies were excluded. IGFBP-1 in the cervicovaginal fluid was measured by a rapid dipstick method (PROM test). AFI was measured by the four-quadrant method and an AFI of <80 mm was considered as oligohydroamnios. The sensitivity, specificity and accuracy of the nitrazine test, the PROM test and AFI were 97, 16 and 56%, 97, 97 and 97% and 94, 91 and 92%, respectively. The nitrazine test results were affected by vaginal discharge but the PROM test results were not affected. Only a positive PROM test was associated with delivery w...Continue Reading

References

Sep 5, 1991·The New England Journal of Medicine·C J LockwoodT J Garite
Feb 1, 1985·American Journal of Obstetrics and Gynecology·J P PhelanR H Paul
Sep 30, 1996·Clinica Chimica Acta; International Journal of Clinical Chemistry·E M RutanenA L Hartikainen
Apr 16, 1998·Acta Obstetricia Et Gynecologica Scandinavica·E Darj, S Lyrenäs
Mar 4, 1999·The Journal of Obstetrics and Gynaecology Research·T Kubota, H Takeuchi
Aug 15, 2000·American Journal of Obstetrics and Gynecology·S T VermillionD E Soper
Jan 31, 2002·Clinics in Perinatology·T J Garite

❮ Previous
Next ❯

Citations

May 24, 2008·Human Reproduction Update·Laura MaintzNatalija Novak
Jan 28, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Seung Mi LeeBo Hyun Yoon
Mar 4, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Gian Carlo Di RenzoYves Ville
Apr 8, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Seung Mi LeeBo Hyun Yoon
Nov 11, 2011·The Journal of Obstetrics and Gynaecology Research·Vorapong Phupong, Vatinee Sonthirathi
Feb 23, 2012·The Journal of Obstetrics and Gynaecology Research·Mansooreh S Zanjani, Ladan Haghighi
Dec 8, 2010·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Peter R L Neil, Euan M Wallace
Mar 21, 2013·The Journal of Obstetrics and Gynaecology Research·Shohreh BahasadriShokoufeh Khalili
Mar 13, 2014·The Journal of Obstetrics and Gynaecology Research·Ibrahim A Abdelazim
Aug 26, 2014·Acta Obstetricia Et Gynecologica Scandinavica·Hanna KallioniemiJorma Paavonen
Jul 27, 2014·American Journal of Obstetrics and Gynecology·Nelson C EchebiriNora M Doyle
Feb 12, 2013·Journal de gynécologie, obstétrique et biologie de la reproduction·L BlanchonD Gallot
Jan 10, 2012·Journal de gynécologie, obstétrique et biologie de la reproduction·D GallotH Fernandez
Feb 2, 2015·Journal de gynécologie, obstétrique et biologie de la reproduction·M LecerfM Dreyfus
Sep 25, 2012·Current Opinion in Obstetrics & Gynecology·David P van der HamBen W J Mol

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.