Significance of elevated procollagen-III-peptide and transforming growth factor-beta levels of bronchoalveolar lavage fluids from idiopathic pulmonary fibrosis patients

The Tohoku Journal of Experimental Medicine
N HiwatariK Shirato

Abstract

Although both procollagen III aminopeptide (P-III-P) and transforming growth factor-beta (TGF-beta) are reported to be present in lung tissue and/or elevated in bronchoalveolar lavage fluid (BALF) from idiopathic pulmonary fibrosis (IPF) patients, we have little knowledge concerning the clinical significance of elevated P-III-P and TGF-beta levels in BALF. Using a radioimmunoassay, we measured P-III-P and TGF-beta in BALF from 48 IPF patients (16F and 32M, 59 +/- 2 years, mean +/- S.E.) who received BAL in our clinic over the past 13 years before glucocorticosteroid treatment. Among them, we could detect a significant amount of P-III-P (2.2 +/- 1.0 U/ml; range 0.03 to 16.5 U/ml) in BALF in 18 of the patients (5F and 13M, 58 +/- 3 years) (group B). but not (0.03 U/ml or less) in the other 30 patients (11F and 19M, 59 +/- 2 years) (group A). Lymphocyte (%) and basophil (%) in BALF from group B was much larger than that from group A (33% vs. 8%, p < 0.01). Group B showed a longer duration of onset to BAL (36 months vs. 23 months, p < 0.05). TGF-beta levels were obtained using an ELISA system kit from the same BALF samples. TGF-beta was not detected in 10 patients (100 pg/ml or less) (3F and 7M, 59 +/- 4 years) (group I), while the...Continue Reading

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Citations

Dec 12, 2012·Proceedings of the National Academy of Sciences of the United States of America·Meenakshi MaitraChristine Kim Garcia
Nov 9, 2010·American Journal of Respiratory Cell and Molecular Biology·Laszlo FarkasMartin Kolb
Mar 9, 2013·American Journal of Respiratory Cell and Molecular Biology·Ragini VittalDavid S Wilkes
Aug 10, 2000·Environmental Health Perspectives·J A Lasky, A R Brody
Aug 9, 2012·Biomarker Insights·Tianhui LiuFederica Genovese
Jun 13, 2014·American Journal of Respiratory and Critical Care Medicine·Anna P LamCara J Gottardi
Oct 7, 2010·Expert Review of Respiratory Medicine·Aaron GardnerAndrew J Fisher
Jul 22, 2016·The Tohoku Journal of Experimental Medicine·Xiang HuangYanhong Gu
Jul 12, 2018·Molecular Biology of the Cell·Elizabeth Monaghan-BensonKeith Burridge
May 15, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Shilpa Vyas-ReadBrigham C Willis
May 6, 2003·Scandinavian Journal of Clinical and Laboratory Investigation·H WolffH Riska
Aug 8, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Yet H KhorAnne E Holland
Sep 15, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Johanna SalonenRiitta Kaarteenaho
Feb 11, 2004·Chest·Ulrike Bartram, Christian P Speer

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