Significance of Eosinophils in Promoting Pancreatic malignancy

Journal of Gastroenterology, Pancreatology & Liver Disorders
Murli ManoharAnil Mishra

Abstract

Several reports indicate that eosinophils are induced in chronic pancreatitis including patients with pancreatic malignancy. However, significance of eosinophilic pancreatitis (EP) is poorly understood and unexplored. Accumulation and degranulation of eosinophils promote pancreatic fibrosis and malignancy. Human pancreatic tissue biopsy samples including chronic pancreatitis (n=3), malignant (n=4), non-malignant (n=3), and normal (n=3) were used for H&E, anti-MBP staining, anti-tryptase staining, anti-IgE staining and Mason's trichrome staining. We show induced eosinophils and degranulated eosinophils indicated by the presence of anti-MBP stained extracellular granules in the malignant pancreatic (pancreatic cancer) and non-malignant human pancreatic tissues. A comparable number of eosinophils were observed in non-malignant and malignant pancreatic tissue sections, but the sections differed in degranulated eosinophils and the presence of extracellular granules. Additionally, induced mast cells and tissue-specific IgE positive cells were also detected in the tissue sections of malignant pancreatitis patients compared to non-malignant human pancreatic patients. Tissue-specific IgE induction is critical for the degranulation of eo...Continue Reading

Citations

Apr 21, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·K Holub, C Conill
Jun 20, 2020·Cell Communication and Signaling : CCS·Sarah B GittoDeborah A Altomare
Mar 31, 2021·Seminars in Immunopathology·Murli ManoharAnil Mishra
May 24, 2019·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·Larisa Pinte, Cristian Băicuș
Jun 30, 2021·Life Science Alliance·Hemanth Kumar KandikattuAnil Mishra
Jul 6, 2021·Proceedings·Rebekah JohnJonathan Ramirez

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