Significance of eosinophiluria in urinary schistosomiasis. A study using Hansel's stain and electron microscopy

American Journal of Clinical Pathology
I A EltoumM Homeida

Abstract

Urine deposit smears of 58 patients with urinary schistosomiasis, 20 with acute glomerulonephritis, and 14 with urinary stones were stained with Hansel's stain. Eosinophiluria was seen in all cases of urinary schistosomiasis (median 0.73 [73%] of urinary white blood cells [WBCs]); 13 (65%) of those with acute glomerulonephritis (median 0.03 [3%] of urinary WBCs); and 2 (14%) patients with urinary stones (0.01 [1%] and 0.05 [5%] of urinary WBCs). Other features included the presence of ova and activated macrophages and giant cells in urinary schistosomiasis, an increased number of mononuclear cells and stained cellular casts in acute glomerulonephritis, and an increased number of neutrophils in urinary stones. In schistosomiasis, urine differential leukocyte counts were unrelated to those of the blood. Moreover, urine eosinophil percentages were always higher than those in the blood. Thus, in urinary schistosomiasis, eosinophiluria could be explained by exudation, sloughing of granulomata, as well as bleeding from the urinary tract surface. Electron microscopic examination confirmed that most of the leukocytes were eosinophils. Some of these were adherent and degranulating over ova with variable miracidial damage. Urine eosinoph...Continue Reading

Citations

Apr 6, 2012·PLoS Pathogens·Chi-Ling FuMichael H Hsieh
May 1, 1993·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·I A EltoumM M Homeida
Jul 18, 2014·PLoS Neglected Tropical Diseases·Charles Emile RamarokotoBirgitte Jyding Vennervald
Nov 23, 2017·Transactions of the Royal Society of Tropical Medicine and Hygiene·Chalotte Willemann StecherMoussa Sacko
Jul 28, 2001·Kidney International·J Rossert

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