Significance of glucagon for insulin secretion and hepatic glycogenolysis during exercise in rats

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
E A RichterB Sonne

Abstract

The significance of glucagon and of the sympatho-adrenal system for insulin secretion and hepatic glycogen depletion during exercise was studied. Male rats were either adrenodemedullated and chemically sympathectomized with 6-hydroxydopamine (SX) or sham-treated (C). During light ether anesthesia, cardiac blood for glucose analysis and a biopsy of the liver were obtained, and either antigen-stripped glucagon antibodies (A) or control gamma globulins (N) in saline were injected through the cardiac cannula. Subsequently, the rats swam in tepid water (33-34 degree C) for 100 minutes with a tail weight attached (2% of body weight). Then cardiac blood was drawn for analysis of glucose, insulin and glucagon, and a sample of the liver was collected. In both CA and CN rats, the blood glucose concentration tended to increase (p less than 0.1) during exercise, whereas hepatic glycogen depletion and the plasma insulin concentration were lower in CA rats compared to CN rats. In SX rats, the blood glucose concentration did not increase during exercise, and in SXA but not in SXN rats, the hepatic glucogen depletion was lower than in CN rats. The plasma insulin concentration was consistently higher in SX rats than in C rats, and was significa...Continue Reading

Citations

Mar 1, 1994·Acta Physiologica Scandinavica·G Van DijkA B Steffens
Jan 1, 1989·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·S E Terblanche
Sep 1, 1992·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·F Pérez-LlamasJ F Sastre
Jun 1, 1991·The American Journal of Physiology·D H Wasserman, A D Cherrington
Jul 1, 1989·The American Journal of Physiology·D H WassermanA D Cherrington
Sep 1, 1995·The American Journal of Physiology·C L BrandJ J Holst
Jun 1, 1986·The American Journal of Physiology·D A ArnallW W Winder
Jan 1, 1981·The American Journal of Medicine·E A RichterS H Schneider

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