PMID: 591099Jan 1, 1977

Significance of Hageman factor (coagulation factor XII) for neutrophil locomotion and chemotaxis

International Archives of Allergy and Applied Immunology
H U KellerH Cottier


Neutrophils separated from Hageman factor-deficient blood exhibit normal random and directional locomotion. No defect in cytotaxin formation could be demonstrated in Hageman factor-deficient plasma, nor did kallikrein inhibitor interfere with the chemotactic activity of normal immune complex-activated human plasma. The results suggest that the chemotactic activity which is detectable in unfractionated human plasma is not derived from Hageman factor-dependent pathways.


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Related Concepts

Immune complex
Cell Motility
Chemotaxis, Leukocyte
Factor XII
Factor XII Deficiency
Neutrophil Band Cells
Extrinsic Plasminogen Activators

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