PMID: 591099Jan 1, 1977

Significance of Hageman factor (coagulation factor XII) for neutrophil locomotion and chemotaxis

International Archives of Allergy and Applied Immunology
H U KellerH Cottier

Abstract

Neutrophils separated from Hageman factor-deficient blood exhibit normal random and directional locomotion. No defect in cytotaxin formation could be demonstrated in Hageman factor-deficient plasma, nor did kallikrein inhibitor interfere with the chemotactic activity of normal immune complex-activated human plasma. The results suggest that the chemotactic activity which is detectable in unfractionated human plasma is not derived from Hageman factor-dependent pathways.

Citations

Mar 1, 1983·Veterinary Immunology and Immunopathology·G S Smith, J H Lumsden
Jun 1, 1981·The Journal of Experimental Medicine·R C WigginsP M Henson
Nov 27, 2007·British Journal of Pharmacology·Guy A CabralF Marciano-Cabral
Jan 21, 2009·Expert Reviews in Molecular Medicine·Guy A Cabral, LaToya Griffin-Thomas
Mar 27, 2015·Molecular Nutrition & Food Research·Joseph SchwagerDaniel Raederstorff

Related Concepts

Immune complex
Cell Motility
Chemotaxis, Leukocyte
Factor XII
Factor XII Deficiency
Padutin
Kaolinite
Neutrophil Band Cells
Extrinsic Plasminogen Activators

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