Significance of heparanase in metastatic lymph nodes of cervical squamous cell cancer

Oncology Letters
Bin HuJinquan Cui

Abstract

The aim of this study was to explore the expression of heparanase (HPA) in metastatic lymph nodes (LNs) of cervical cancer and to evaluate HPA as a marker of micro-metastasis of LNs. Immunohistochemistry was performed to detect the expression of HPA in 53 cases with metastasis of LNs (group A) and 49 cases without (group B). Scoring was determined based on the intensity of immunostaining and the size of the staining area. Three points or higher score was considered as positive. Among all cases, the positive rate of HPA was 76.5% in primary lesions and 84.9% in both primary lesions and metastatic LNs in group A. In group B, the rates were 67.3% in primary lesions and 8.2% in metastatic LNs. The expression of HPA in group A was significantly higher than that in group B (P<0.05). Compared with stage IA-IB and well-differentiated and non-metastatic LNs, the LNs of stage IIA and moderately/poorly differentiated and metastatic LNs expressed higher HPA (P<0.05). The overall 5-year survival rate was 73.3% and the median overall survival time (MOS) was 49.0 months. The MOS of the two groups was 36.0 and 58.5 months, respectively (P=0.023); the MOS of patients with positive HPA expression was distinctly lower than that of negative patien...Continue Reading

References

Sep 25, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Y ShinyoY Hiramatsu
Apr 1, 2005·Neoplasia : an International Journal for Oncology Research·Hagit DafniMichal Neeman
Sep 10, 2005·Best Practice & Research. Clinical Obstetrics & Gynaecology·W A A TjalmaJ J P M Bogers
Feb 14, 2006·Oncogene·L BarazI Vlodavsky
May 10, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H Y WangS Q Fu
Dec 13, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M A QuinnS Pecorelli
Dec 23, 2006·Nature Reviews. Cancer·Ciaran B J WoodmanLawrence S Young
Sep 18, 2008·International Journal of Cancer. Journal International Du Cancer·Victoria Cohen-KaplanIlana Doweck
Feb 5, 2010·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Jiri SlamaDavid Cibula
Oct 4, 2012·Journal of Experimental & Clinical Cancer Research : CR·Ryuki OzasaKunihisa Taniguchi
Dec 5, 2012·Vaccine·David FormanSilvia Franceschi
Aug 13, 2013·Obstetrics and Gynecology International·G HosteW A J Poppe
Nov 14, 2013·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Jaime Prat, UNKNOWN FIGO Committee on Gynecologic Oncology
Nov 30, 2013·Journal of Cellular and Molecular Medicine·Nir HirshorenMichael Elkin
Feb 20, 2014·Frontiers in Oncology·Despoina BarbouriNikos K Karamanos
Feb 26, 2014·Biochemical Pharmacology·Claudio PisanoFranco Zunino
Nov 1, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M A QuinnS Pecorelli

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Citations

Nov 6, 2018·World Journal of Gastroenterology : WJG·Li-Ping LiuYu-Min Li

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