Significance of hepatitis C virus coinfection with persistently normal alanine aminotransferase levels in HIV-1-infected patients

HIV Medicine
L FonquernieJ L Meynard

Abstract

To assess the prevalence of chronic hepatitis C virus (HCV) infection with persistently normal alanine aminotransferase (ALT) levels in HIV-1-infected patients, together with its clinical, biological and histological characteristics and predictive factors. We retrospectively studied all HCV/HIV-coinfected patients treated in our Infectious Diseases Department, for whom data on both HIV and HCV infection were available. We compared the demographic characteristics and parameters of HIV and HCV infection between cases, defined by persistently normal ALT levels (<45 IU/L) and detectable serum HCV-RNA (determined by PCR), and controls with high ALT levels and HCV PCR positivity during the previous 3 years. Among the 815 HIV-infected patients assessed for this study, 179 (22%) were HCV-coinfected, of whom 155 were eligible for this analysis. Of these 155 HCV-coinfected patients, 137 (88%) were HCV-PCR-positive, of whom 39 (28.5%) had persistently normal ALT levels (cases) and 98 (71.5%) had high ALT levels (controls). Relative to controls, cases had a significantly lower fibrosis score and a lower fibrosis progression rate (2.2 vs. 1.3, P=0.004; 0.3 vs. 0.2, P=0.006, respectively). Three factors associated with persistently normal AL...Continue Reading

References

Feb 1, 1991·The Journal of Infectious Diseases·K E ShermanL Andron
Mar 21, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P MathurinT Poynard
Sep 25, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y BenhamouT Poynard
Jun 22, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H K MongaB Yoffe
Jul 20, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C S GrahamM J Koziel
Aug 2, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y BenhamouUNKNOWN MultivirC Group
Oct 27, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M Martinot-PeignouxP Marcellin

❮ Previous
Next ❯

Citations

Feb 25, 2005·Current Infectious Disease Reports·Benigno Rodriguez, David A Bobak
Aug 4, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Matilde Sánchez-CondeEmilio Alvarez
Aug 30, 2008·AIDS Patient Care and STDs·Maria Cássia Mendes-CorreaReinaldo José Gianini
Jun 6, 2009·HIV Medicine·F Bani-SadrUNKNOWN ANRS HC02 - Ribavic Study Team
Aug 13, 2009·World Journal of Gastroenterology : WJG·Ashwani-K Singal, Bhupinderjit S Anand
Dec 13, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Caterina Uberti-FoppaAdriano Lazzarin
May 3, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Stevan A GonzalezAndrew H Talal
Apr 29, 2011·Digestive Diseases and Sciences·Amy G ShahRichard K Sterling
Nov 30, 2010·Clinics in Liver Disease·Shehzad N Merwat, John M Vierling
Nov 10, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·P SellierC Lafuente-Lafuente
Jul 30, 2008·British Journal of Clinical Pharmacology·Sofia A PereiraEmília C Monteiro
Aug 30, 2012·Revista Da Sociedade Brasileira De Medicina Tropical·Fábio Heleno de Lima PaceMaria Lucia Gomes Ferraz
Sep 25, 2008·Revista Do Instituto De Medicina Tropical De São Paulo·Maria Cássia Mendes-CorreaReinaldo José Gianini
Jan 15, 2010·Journal of the International Association of Physicians in AIDS Care : JIAPAC·Nathan J ShoresMarina Núñez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.