Significance of histologic tumor grade in rectal cancer treated with preoperative chemoradiotherapy followed by curative surgery: A multi-institutional retrospective study

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Jin Ho SongKi Mun Kang

Abstract

To evaluate the pre-treatment clinical factors affecting recurrence and survival in rectal cancer patients who receive preoperative chemoradiotherapy (CRT) and curative surgery. The clinical data of 1782 patients from 8 institutions in Korea were analyzed. The potential prognostic factors that could be acquired before radical surgery were patient age, gender, clinical T and N stages, tumor size and location, tumor grade, carcinoembryonic antigen (CEA) level, and the concurrent chemotherapy regimen. The relapse-free survival (RFS), overall survival (OS), and cumulative incidence of locoregional and distant recurrence were analyzed according to the clinical factors. Among the pre-treatment clinical factors, tumor grade, pre-CRT CEA level, tumor location, and clinical N stage were significant prognostic factors affecting the RFS. The high-grade tumor was the hazardous factor for RFS on the multivariate analysis [Hazard ratio (HR), 1.83; 95% confidence interval (CI), 1.29-2.58; p=0.001]. The 5-year RFS rate for high-grade tumors was significantly lower than that for low-grade tumors (63.8% vs. 78.8%, p<0.001). The tumor grade was a significant prognostic factor for distant recurrence (HR, 1.83, 95% CI, 1.29-2.58; p<0.001), but not ...Continue Reading

References

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Citations

Mar 9, 2017·International Journal of Molecular Sciences·Delphine DaydeAyumu Taguchi
Oct 19, 2017·Radiation Oncology Journal·Jin Ho SongUNKNOWN Korean Clinical Practice Guideline for Colon and Rectal Cancer Committee
Dec 4, 2019·World Journal of Surgery·Leah E HendrickPaxton V Dickson
May 31, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jung Wook HuhHo-Kyung Chun

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