Significance of IL-1beta and IL-1 receptor antagonist (IL-1Ra) in bronchoalveolar lavage fluid (BALF) in patients with diffuse panbronchiolitis (DPB)

Clinical and Experimental Immunology
J KadotaS Kohno

Abstract

We evaluated the effect of erythromycin therapy on pulmonary function tests and the airway inflammatory response of patients with DPB. The number of neutrophils in BALF obtained from DPB patients was significantly higher than that of healthy volunteers. Treatment with erythromycin (600 mg/day for 12.9+/-9.5 months (mean +/- s.d.)) significantly reduced the total number of cells and neutrophils in the airway, and significantly improved pulmonary function tests. The levels of IL-1beta and IL-8 were significantly higher in DPB compared with healthy volunteers (P<0.05, P<0.05, respectively). IL-1Ra in patients is considered to have a weak inhibitory activity for IL-1beta, with approximately five-fold concentration of IL-1beta compared with that in healthy volunteers (approx. nine-fold concentration of IL-1beta). Erythromycin therapy significantly reduced these cytokines to levels comparable to those of healthy volunteers, and produced a trend toward reduction in the level of IL-1Ra in BALF. The level of IL-1beta correlated significantly with the concentration of neutrophils in BALF (r=0.72, P<0.01), as well as with the level of IL-1Ra (r=0.688, P<0.05) and IL-8 (r=0.653, P<0.05). A nearly significant or significant correlation was ...Continue Reading

References

Jun 1, 1992·American Journal of Respiratory Cell and Molecular Biology·S A MooreS L Kunkel
Nov 1, 1991·Immunology Today·C A Dinarello, R C Thompson
Jan 1, 1991·Annual Review of Immunology·J J OppenheimK Matsushima
May 1, 1990·The Journal of Clinical Investigation·W P ArendS P Eisenberg
Oct 1, 1989·The Journal of Clinical Investigation·M BaggioliniS L Kunkel
Sep 1, 1987·The American Review of Respiratory Disease·J T ZakrzewskiP J Piper
Apr 1, 1982·Thorax·B R O'Driscoll, A B Kay
Jan 1, 1995·Clinical Immunology and Immunopathology·D M Chang
Sep 1, 1994·American Journal of Respiratory and Critical Care Medicine·W D ClappD A Schwartz
Jan 1, 1993·The American Review of Respiratory Disease·J KadotaK Hara

❮ Previous
Next ❯

Citations

Mar 14, 2007·Journal of Occupational and Environmental Medicine·Arun B JosyulaJefferey L Burgess
Feb 12, 2002·Pharmacotherapy·Allyson S Gaylor, Joan C Reilly
Oct 12, 2010·American Journal of Respiratory Cell and Molecular Biology·Tomoyuki FujisawaReen Wu
May 23, 1998·Annual Review of Immunology·W P ArendC Gabay
Apr 21, 2018·Immunology·Thomas ScamblerDaniel Peckham
Dec 12, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·J Zalewska-Kaszubska, D Górska
Oct 7, 2004·Biochemical and Biophysical Research Communications·Seoung-Ju ParkHeung-Bum Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.