Abstract
We evaluated the effect of erythromycin therapy on pulmonary function tests and the airway inflammatory response of patients with DPB. The number of neutrophils in BALF obtained from DPB patients was significantly higher than that of healthy volunteers. Treatment with erythromycin (600 mg/day for 12.9+/-9.5 months (mean +/- s.d.)) significantly reduced the total number of cells and neutrophils in the airway, and significantly improved pulmonary function tests. The levels of IL-1beta and IL-8 were significantly higher in DPB compared with healthy volunteers (P<0.05, P<0.05, respectively). IL-1Ra in patients is considered to have a weak inhibitory activity for IL-1beta, with approximately five-fold concentration of IL-1beta compared with that in healthy volunteers (approx. nine-fold concentration of IL-1beta). Erythromycin therapy significantly reduced these cytokines to levels comparable to those of healthy volunteers, and produced a trend toward reduction in the level of IL-1Ra in BALF. The level of IL-1beta correlated significantly with the concentration of neutrophils in BALF (r=0.72, P<0.01), as well as with the level of IL-1Ra (r=0.688, P<0.05) and IL-8 (r=0.653, P<0.05). A nearly significant or significant correlation was ...Continue Reading
References
Oct 1, 1992·The Journal of Clinical Investigation·N G McElvaneyR G Crystal
Nov 1, 1992·Infection and Immunity·C PalmaJ Y Djeu
Oct 1, 1992·Journal of Applied Physiology·J N KlineG W Hunninghake
Jun 1, 1992·American Journal of Respiratory Cell and Molecular Biology·S A MooreS L Kunkel
Jul 1, 1992·The American Review of Respiratory Disease·Y IchikawaK Oizumi
Nov 1, 1991·Immunology Today·C A Dinarello, R C Thompson
Feb 1, 1991·The Journal of Investigative Dermatology·M K ThomsenK Thestrup-Pedersen
Jan 1, 1991·Annual Review of Immunology·J J OppenheimK Matsushima
Mar 1, 1991·Chest·S NagaiT Izumi
Jan 25, 1990·Nature·C H HannumR C Thompson
Apr 12, 1990·Nature·D B CarterR N McEwan
May 1, 1990·The Journal of Clinical Investigation·W P ArendS P Eisenberg
Sep 1, 1989·The Journal of Experimental Medicine·J M Schröder
Oct 1, 1989·The Journal of Clinical Investigation·M BaggioliniS L Kunkel
Sep 1, 1987·The American Review of Respiratory Disease·J T ZakrzewskiP J Piper
Oct 1, 1988·Chest·S NagaiT Izumi
Apr 1, 1982·Thorax·B R O'Driscoll, A B Kay
Jan 1, 1983·Chest·H HommaT Izumi
Jul 1, 1995·Chest·H OdaK Hara
Oct 1, 1994·Infection and Immunity·K OishiK Matsumoto
Jan 1, 1995·Clinical Immunology and Immunopathology·D M Chang
Sep 1, 1994·American Journal of Respiratory and Critical Care Medicine·W D ClappD A Schwartz
Aug 21, 1993·Lancet·R Lawrence, T Sorrell
Jul 1, 1993·Chest·J N KlineG W Hunninghake
Jan 1, 1993·The American Review of Respiratory Disease·J KadotaK Hara
Citations
Jul 3, 2004·Allergy·S KatohS Matsukura
Jun 16, 2005·International Archives of Allergy and Immunology·Shigeki KatohMitsuomi Hirashima
Mar 14, 2007·Journal of Occupational and Environmental Medicine·Arun B JosyulaJefferey L Burgess
Mar 13, 2002·Transplantation·John A BelperioRobert M Strieter
Feb 12, 2002·Pharmacotherapy·Allyson S Gaylor, Joan C Reilly
May 22, 2003·Allergy·S KatohS Matsukura
Oct 12, 2010·American Journal of Respiratory Cell and Molecular Biology·Tomoyuki FujisawaReen Wu
Feb 25, 2000·Allergy·S KatohS Kohno
Dec 12, 2001·Clinical and Experimental Immunology·S KatohS Kohno
Apr 9, 2010·International Journal of Rheumatic Diseases·Shahram SadreddiniMorteza Ghojazadeh
May 23, 1998·Annual Review of Immunology·W P ArendC Gabay
Apr 21, 2018·Immunology·Thomas ScamblerDaniel Peckham
Jul 3, 2016·Chemico-biological Interactions·Marinelli OlivieroNabissi Massimo
Dec 12, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·J Zalewska-Kaszubska, D Górska
Oct 7, 2004·Biochemical and Biophysical Research Communications·Seoung-Ju ParkHeung-Bum Lee