Significance of increased factor VIII in early glomerulonephritis.

Annals of Internal Medicine
M EkbergF Linell

Abstract

One hundred sixteen patients with early glomerulonephritis had factor VIII without impairment of renal function. They also had other coagulation and fibrinolytic components and acute phase reactants. The patients were followed for up to 4 years with respect to both coagulation pattern and renal function. Patients who made a complete recovery during follow-up had normal initial factor VIII levels, while those who developed persistent renal damage had high factor VIII levels. The other coagulation factors and the acute phase reactants were of no prognostic significance. Factor VIII has been shown to be synthesized in the vessel intima. The initial factor VIII level in early glomerulonephritis may reflect the degree of vascular affection of the glomeruli. The high factor VIII levels may be of significance for the development of fibrin deposits in glomeruli.

Citations

Jul 1, 1981·Acta diabetologica latina·C VerganiP M Mannucci
Aug 1, 1995·Thrombosis Research·J KłoczkoE Tarasów
Dec 1, 1980·British Journal of Haematology·J J Sixma
Jun 1, 1987·Annals of the Rheumatic Diseases·A D WoolfP A Dieppe
Jul 1, 1985·Mayo Clinic Proceedings·S T PersellinG G Hunder
Nov 1, 1983·Kidney International·D Deykin
Nov 1, 1983·Thrombosis Research·L Zheng
Jan 1, 1987·Rheumatology International·L PuccettiM L Ciompi
Apr 19, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Walter G Wasser, Etty Kruzel-Davila
Jan 1, 1988·Scandinavian Journal of Rheumatology·M L CiompiP Iacconi
Dec 1, 1984·Arthritis and Rheumatism·S R NusinowJ G Curd
Oct 1, 1982·La Ricerca in Clinica E in Laboratorio·G LeoneB Bizzi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.