Significance of initial ST segment elevation and depression for the management of thrombolytic therapy in acute myocardial infarction. European Cooperative Study Group for Recombinant Tissue-Type Plasminogen Activator

Circulation
J L WillemsM Verstraete

Abstract

To determine the ability of initial ST segment elevation and depression to predict infarct size limitation by thrombolytic therapy, data were analyzed in 721 patients with acute myocardial infarction who were admitted to a randomized, placebo-controlled study of intravenous recombinant tissue-type plasminogen activator. Patients with QRS duration of 120 msec or more or with previous history of myocardial infarction were excluded, leaving 322 in the treatment and 333 in the placebo group. Cumulative 72-hour release of alpha-hydroxybutyrate dehydrogenase and global ejection fraction as well as left ventricular wall motion derived from angiography were used as independent measures of infarct size. Electrocardiograms obtained at admission, 6 hours after start of therapy, and before discharge were analyzed. All ST measurements were made by hand at the J point and 60 msec after the J point. Patients with high ST segment elevation at admission (i.e., sum of ST elevation at 60 msec after the J point was 20 mm or more) had significantly larger infarction and higher hospital mortality when compared with those with lower (less than 20 mm) ST elevation. Reciprocal ST segment depression also showed a linear relation with infarct size and mo...Continue Reading

References

Sep 1, 1979·British Heart Journal·S YusufP Sleight
Aug 1, 1989·Journal of the American College of Cardiology·H SatoT Kamada
Feb 1, 1989·The American Journal of Cardiology·W E Boden, D H Spodick
Dec 1, 1988·Journal of the American College of Cardiology·E Braunwald
Apr 1, 1987·Journal of Electrocardiology·N B Hindman, G S Wagner
Apr 15, 1986·The American Journal of Cardiology·M W KrucoffC E Rackley

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Citations

Jan 15, 2013·Journal of Cardiovascular Translational Research·Thomas Cuisset, Jacques Quilici
Sep 30, 1994·Atherosclerosis·P M CliftonP J Nestel
Nov 1, 1993·Journal of the American College of Cardiology·T LindererJ Wagner
Apr 1, 1996·Journal of the American College of Cardiology·Y BirnbaumG I Barbash
May 1, 1995·Progress in Cardiovascular Diseases·E W GrijseelsM L Simoons
Jun 27, 1998·Lancet·C H Davies, O J Ormerod
Nov 3, 2001·Journal of the American College of Cardiology·J A de Lemos, E Braunwald
Aug 1, 1997·Journal of the American College of Cardiology·E R Bates
Dec 3, 2009·European Heart Journal·Michael C TjandrawidjajaUNKNOWN APEX-AMI Investigators
Mar 15, 2006·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Stephen W Smith
Dec 20, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Masayoshi KiyokuniKazuo Kimura
Apr 2, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Koichi HanadaSatoshi Umemura
Sep 10, 2014·The American Journal of Cardiology·Lucy J BoothroydPeter Bogaty

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