Abstract
Invasive ductal carcinoma (IDC) of breast metastatic to axillary lymph node (ALN) is a critical factor in determining stage and is a strong predictor of disease prognosis and survival. We studied ALN metastasis using a combined histopathologic/molecular approach to gain insights into the pathobiology implications. Fourteen patients with IDC with positive ALN and 19 with negative ALN were retrieved. Analysis of 17 polymorphic microsatellite repeat markers targeting 1p34-36, 3p24-26, 5q23, 9p21, 10q23, 17p13, 17q12, 17q21, 21q22, and 22q13 was carried out in DNA isolated from primary tumors and metastatic tumors. ALN metastasis correlated with fractional mutation rate of primary and ALN metastatic tumors, primary tumor size, and nuclear grade, and did not correlate with expression of estrogen receptor, progesterone receptor, and Her2/neu. Loss of heterozygosity (LOH) detected at 1p34-36, 3p24-26, 9p21, 10q23, 17p13, 17q12, 21q22, and 22q13 may play an important role in the development and aggressiveness of IDC, and LOHs at 1p34-36, 17p13, and 22q13 may play an important role in metastasis. None of the LOHs were shared by all the tumors, suggesting that IDC develops through various pathways that have unique and personalized patter...Continue Reading
References
Apr 1, 1992·Journal of the National Cancer Institute·L C ChenH S Smith
Jul 1, 1997·Genes, Chromosomes & Cancer·K DriouchR Lidereau
Aug 1, 1997·Genes, Chromosomes & Cancer·T NishizakiF M Waldman
Jul 4, 1998·British Journal of Cancer·K L Marsh, J M Varley
Sep 22, 1998·British Journal of Cancer·A SchwendelM Dietel
Apr 22, 1999·The Journal of Surgical Research·D M EuhusA F Gazdar
Dec 11, 1999·Cancer·R L CampD L Rimm
Mar 16, 2000·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·M M AubeleM Werner
May 29, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·P L DepowskiJ S Ross
Dec 7, 2000·Pathology International·M HoriM Hori
Jul 5, 2001·The American Journal of Pathology·A MaitraJ D Minna
Jul 6, 2001·The Journal of Pathology·S SeitzS Scherneck
Sep 29, 2001·Molecular Pathology : MP·A MartinezF Latif
Jul 19, 2002·International Journal of Cancer. Journal International Du Cancer·Evgeny N ImyanitovCharles Theillet
Aug 2, 2002·Breast Cancer Research and Treatment·Sebastian AulmannHans Peter Sinn
Mar 13, 2003·Breast Cancer Research : BCR·Patnala Mohan R AcharyBhadrasain Vikram
Jun 6, 2003·Histopathology·Y Umekita, H Yoshida
Jul 5, 2003·The International Journal of Biological Markers·V SorbelloM De Bortoli
Nov 25, 2003·Pathology International·Satoshi IkedaMorio Koike
Dec 4, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael A GonzalezNicholas Coleman
Dec 3, 2003·The Journal of Pathology·Emiel A M JanssenMario A J A Hermsen
Dec 9, 2003·The Breast : Official Journal of the European Society of Mastology·P BourgeoisD Larsimont
Mar 5, 2004·Breast Cancer Research and Treatment·Ben DavidsonJahn M Nesland
Apr 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ute WoelfleKlaus Pantel
Aug 4, 2004·Cancer Research·Aruna SomasiriCalvin D Roskelley
Nov 3, 2004·Cancer Research·Sucharita BandyopadhyayKounosuke Watabe
Nov 30, 2004·Breast Cancer Research and Treatment·Gilbert SpizzoGuenther Gastl
Nov 30, 2004·Breast Cancer Research and Treatment·Gernot HudelistKlaus Czerwenka
May 25, 2005·Histopathology·E A RakhaI O Ellis
Jun 4, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Emiliano HonradoJosé Palacios
Jun 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nina LinderHeikki Joensuu
Oct 26, 2005·Cancer Letters·Marco A Pierotti, Angela Greco
Feb 7, 2006·Breast Cancer Research : BCR·Aki MorikawaWei Zhou
Feb 8, 2006·Journal of Clinical Pathology·A E PintoJ Soares
Apr 11, 2006·The Journal of Pathology·P S LarsonC L Rosenberg
Sep 27, 2006·The American Journal of Surgical Pathology·Ricardo R FonsecaJorge Soares
Oct 25, 2006·British Journal of Cancer·B OrsettiC Theillet
Nov 30, 2006·Oncogene·S A MehtaH Nakshatri
Dec 18, 2007·Oncogene·S NowackiM Fischer
Jul 17, 2008·Journal of Molecular Endocrinology·Xiaoqi LinJan F Silverman
Aug 23, 2008·Genes, Chromosomes & Cancer·L W M LooP L Porter