Significance of mild cytologic atypia in women infected with human immunodeficiency virus

Obstetrics and Gynecology
T C WrightN VanDevanter

Abstract

To determine the prevalence of cervical intraepithelial neoplasia (CIN) in women who are infected with human immunodeficiency virus (HIV) and who have mild cytologic atypia. As part of an ongoing, prospective study of cervical disease in HIV-infected women, Papanicolaou smears were analyzed cross-sectionally for the diagnosis of mild cytologic atypia. Mild cytologic atypia was diagnosed in 112 (25%) of the 453 HIV-infected women enrolled in this study, compared with 36 (9%) of the 401 HIV-uninfected women (odds ratio [OR] 3.3, 95% confidence interval [CI] 2.2-5.1; P < .001). Mild cytologic atypia was diagnosed more frequently in HIV-infected women with lower CD4+ T-lymphocyte counts (chi2 for trend, P = .015) and in those with a history of an abnormal Papanicolaou smear or treatment for cervical disease (OR 3.0, 95% CI 1.2-7.6; P = .008). Coexistent CIN was detected by colposcopically directed biopsy in 42 (38%) of the 112 HIV-infected women with mild cytologic atypia, compared with five (14%) of the 36 HIV-uninfected women (OR 3.7, 95% CI 1.3-11.9; P = .008). Severe inflammation with associated epithelial reparative atypia was diagnosed in 90 (20%) of the HIV-infected women and in 87 (22%) of the HIV-uninfected women. Coexiste...Continue Reading

References

May 31, 1994·European Journal of Obstetrics, Gynecology, and Reproductive Biology·E Diakomanolis

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Citations

May 1, 1997·Clinics in Dermatology·J M Palefsky
Feb 15, 2001·AIDS Research and Human Retroviruses·R MarlinkUNKNOWN "Giving Voice to a Silent Epidemic" Working Group
Feb 27, 1999·Current Opinion in Obstetrics & Gynecology·L KuhnT C Wright
May 10, 2001·Clinical Obstetrics and Gynecology·M A Young, R A Clark
May 10, 2001·Clinical Obstetrics and Gynecology·A P Korn
Mar 17, 1999·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·P StrattonM G Fowler
Oct 21, 2011·Journal of Women's Health·Christine L CurryElizabeth A Stier
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A. GoodmanM. L. Hutchinson
Jul 16, 2004·The American Journal of the Medical Sciences·Michael E HagenseeRebecca A Clark
Jun 18, 1998·Primary Care·B S Apgar, L B Zoschnick
Feb 3, 2018·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Carmine CarrieroAntonella Vimercati
Aug 21, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·L S MassadS Melnick
Jan 14, 2005·Current Opinion in Infectious Diseases·Yvonne Gilleece, Ann Sullivan
Oct 23, 1998·Annals of Medicine·C SmithG D Miralles
Apr 24, 2003·Archives of Pathology & Laboratory Medicine·Byron P DemopoulosRita Demopoulos
Jan 16, 1998·Obstetrics and Gynecology Clinics of North America·A P Korn, P D Abercrombie
Jan 1, 1997·Clinical Oncology : a Journal of the Royal College of Radiologists·C P CottrillR H Phillips
Dec 1, 1996·Obstetrics and Gynecology Clinics of North America·T C Wright, X W Sun

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