PMID: 11913358Mar 27, 2002Paper

Significance of morphometric, DNA cytometric features, and other prognostic markers on survival of endometrial cancer patients in northern Norway

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
A ØrboS Lysne

Abstract

The objective of this study was to evaluate the prognostic value of nuclear morphometric features and DNA ploidy by flow cytometry next to depth of myometrial invasion and vascular invasion in endometrial cancer of all FIGO stages. A total of 123 women (103 FIGO stage I, eight stage II, and 12 stage III and IV) from northern Norway were studied. The follow-up period was between 7 and 19 years. The median age of patients was 62 years. The primary surgery was performed in the University Hospital of Tromso or in the seven different reference hospitals in the northern part of Norway after an endometrial cancer diagnosis. The histologic, morphometric,flow cytometric and immunohistochemical investigations were based on archival paraffin-embedded material. The information regarding the follow-up data and clinical information were obtained from the medical records. Thirteen (10.6%) patients from the entire group (all stages) but only three (2.7%) of the FIGO stage I and II patients died from locally recurrent or metastatic disease. FIGO substage (P = 0.0006; odds ratio [OR] =16.44, 95% confidence interval [CI] = 3.36-80.45), vascular invasion (P =0.01, OR = 6.42, CI = 1.57-26.34) and nuclear size (P = 0.025, OR = 1.3,CI = 1.05-1.61) we...Continue Reading

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Citations

May 2, 2006·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Laura CerezoHelen Michael
Oct 4, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M PradhanB Å Risberg
Jan 27, 2007·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Zorica Stanojević, Biljana Dordević
Jun 26, 2010·Archives of Gynecology and Obstetrics·Maria Le DonneVittorio Cavallari
Feb 8, 2005·Histopathology·H Fox
Feb 18, 2014·Cytometry. Part B, Clinical Cytometry·Karen Klepsland MaulandHelga Birgitte Salvesen
Oct 6, 2009·American Journal of Obstetrics and Gynecology·Elisabeth WikHelga B Salvesen

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