Significance of mutations in embB codon 306 for prediction of ethambutol resistance in clinical Mycobacterium tuberculosis isolates.

Antimicrobial Agents and Chemotherapy
Claudia PlinkeStefan Niemann

Abstract

We analyzed 159 Mycobacterium tuberculosis isolates (101 ethambutol [EMB]-resistant strains, 33 multidrug-resistant but not EMB-resistant strains, and 25 fully susceptible strains) for the presence of mutations in embB codon 306 (embB306). Mutations were detected only in EMB-resistant strains (n = 69; 68%), thus confirming the significance of embB306 mutations for the prediction of resistance to EMB.

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Citations

Jun 25, 2013·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Carla SilvaLuisa Jordao
Apr 30, 2010·The Journal of Antimicrobial Chemotherapy·Claudia PlinkeStefan Niemann
Jul 23, 2011·The Journal of Antimicrobial Chemotherapy·Dawei ShiGuofeng Zhu
Jul 2, 2008·Antimicrobial Agents and Chemotherapy·Manzour Hernando HazbónDavid Alland
Dec 24, 2008·Antimicrobial Agents and Chemotherapy·Angela M StarksJames E Posey
Apr 18, 2007·Antimicrobial Agents and Chemotherapy·Xin ShenQian Gao
Jun 25, 2008·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·João PerdigãoIsabel Portugal
Jul 1, 2009·Scandinavian Journal of Infectious Diseases·Young Mi KimSeong-Beom Lee
Feb 27, 2015·Pathology·K M NoorI Bastian
May 19, 2010·Expert Review of Respiratory Medicine·Elvira RichterDoris Hillemann
May 27, 2014·Clinics in Laboratory Medicine·Shou-Yean Grace Lin, Edward P Desmond
Jul 29, 2008·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Violeta ValchevaNadya Markova
Aug 11, 2015·Diagnostic Microbiology and Infectious Disease·Alicia LacomaJose Dominguez
Jul 22, 2014·Tropical Medicine & International Health : TM & IH·Dan ZhangYu Pang
Dec 30, 2008·International Journal of Antimicrobial Agents·G P S JadaunV M Katoch
Jun 25, 2013·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Yuhki NagaiTetsuo Yamaguchi
Jun 28, 2007·Yonsei Medical Journal·Sang-Nae Cho

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