Significance of myocardial tenascin-C expression in left ventricular remodelling and long-term outcome in patients with dilated cardiomyopathy

European Journal of Heart Failure
Tetsuro YokokawaToshihisa Anzai

Abstract

Dilated cardiomyopathy (DCM) has a variety of causes, and no useful approach to predict left ventricular (LV) remodelling and long-term outcome has yet been established. Myocardial tenascin-C (TNC) is known to appear under pathological conditions, possibly to regulate cardiac remodelling. The aim of this study was to clarify the significance of myocardial TNC expression in LV remodelling and the long-term outcome in DCM. One hundred and twenty-three consecutive DCM patients who underwent endomyocardial biopsy for initial diagnosis were studied. Expression of TNC in biopsy sections was analysed immunohistochemically to quantify the ratio of the TNC-positive area to the whole myocardial tissue area (TNC area). Clinical parameters associated with TNC area were investigated. The patients were divided into two groups based on receiver operating characteristic analysis of TNC area to predict death: high TNC group with TNC area ≥2.3% (22 patients) and low TNC group with TNC area <2.3% (101 patients). High TNC was associated with diabetes mellitus. Comparing echocardiographic findings between before and 9 months after endomyocardial biopsy, the low TNC group was associated with decreased LV end-diastolic diameter and increased LV eject...Continue Reading

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Citations

May 21, 2016·European Journal of Heart Failure·Marco Metra
Mar 24, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Hatsue Ishibashi-UedaYoshihiko Ikeda
Nov 7, 2019·Pathology International·Kyoko Imanaka-Yoshida
Jun 21, 2019·Circulation Research·Nikolaos G Frangogiannis
Feb 9, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Toshihisa Anzai
Feb 14, 2019·Proceedings of the National Academy of Sciences of the United States of America·Lindsey N MarshallLaurent Coen
Dec 23, 2017·European Journal of Heart Failure·Marco MerloGianfranco Sinagra
Jul 25, 2019·Journal of Translational Medicine·Li ZhangMo-Jun Lin
Feb 22, 2017·European Journal of Heart Failure·Takafumi NakayamaToshihisa Anzai
Apr 13, 2019·Physiological Genomics·Zarha VermeulenVincent F M Segers
Aug 28, 2020·American Journal of Physiology. Cell Physiology·Kyoko Imanaka-YoshidaToshimichi Yoshida
Feb 24, 2021·Disease Models & Mechanisms·Petra Lujza SzabóKarlheinz Hilber
Mar 7, 2021·International Journal of Molecular Sciences·Mireia Perera-GonzalezBruno Karl Podesser
Jun 3, 2021·International Journal of Molecular Sciences·Kyoko Imanaka-Yoshida
Aug 1, 2021·Advanced Drug Delivery Reviews·Izabela Tuleta, Nikolaos G Frangogiannis
Nov 28, 2021·International Journal of Molecular Sciences·Tomasz Jan KolanowskiMaciej Kurpisz

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Methods Mentioned

BETA
biopsy

Software Mentioned

Statistical Package for Social Sciences
SPSS

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