PMID: 15366639Sep 16, 2004Paper

Significance of non-erosive minimal esophageal lesions in gastro-esophageal reflux disorder

The Korean Journal of Internal Medicine
Sung-Pyo HongJung-Wan Kim

Abstract

Non-erosive reflux disorder, which represents more than 60% of gastro-esophageal reflux disorders, lacks objective parameters for diagnosis. The purpose of this study was to evaluate the correlation between non-erosive minimal lesions at the lower esophagus and gastro-esophageal reflux disorder. Patients were asked to answer a symptom questionnaire. The endoscopic findings were either graded by LA classification or recorded as non-erosive minimal lesions. Patients with minimal lesions were treated with rabeprazole or a placebo and responses were evaluated at weeks 1 and 4. In 8 centers, 3454 patients were screened. In patients with heartburn or acid regurgitation as the most bothersome symptom, 23.7% had endoscopy negative reflux disorder, 40.1% showed minimal lesions, and 36.20% had mucosal break esophagitis. Thirty-four percent of patients with minimal lesions and 39.1% of patients with LA 'grade A' mild esophagitis reported typical reflux symptoms as their main symptom. In patients with minimal lesions, medication with rabeprazole reduced symptoms significantly at weeks 1 and 4, but not with the placebo. Patients with non-erosive minimal esophageal lesions had similar reflux symptoms comparable to those with mild erosive ref...Continue Reading

References

Jan 27, 1990·Lancet·A G KlauserS A Müller-Lissner
Sep 27, 2000·Baillière's Best Practice & Research. Clinical Gastroenterology·R Carlsson, R H Holloway
Oct 25, 2002·Gastrointestinal Endoscopy·John E PandolfinoPeter J Kahrilas

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Citations

Jan 27, 2016·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Han Seung Ryu, Suck Chei Choi

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