Significance of Non-phase Locked Oscillatory Brain Activity in Response to Noxious Stimuli

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
Raphaël Dufort RouleauPhilippe Goffaux

Abstract

Although current pain-evoked electroencephalographic (EEG) studies provide valuable information regarding human brain regions involved in pain, they have mostly considered neuronal responses which oscillate in phase following a painful event. In many instances, cortical neurons respond by generating bursts of activity that are slightly out of phase from trial-to-trial. These types of activity bursts are known as induced brain responses. The significance of induced brain responses to pain is still unknown. In this study, 23 healthy subjects were given both non-painful and painful transcutaneous electrical stimulations in separate testing blocks (stimulation strength was kept constant within blocks). Subjective intensity was rated using a numerical rating scale, while cerebral activity tied to each stimulation was measured using EEG recordings. Induced brain responses were identified using a time frequency wavelet transform applied to average-removed single trials. Results showed a pain-specific burst of induced theta activity occurring between 180 and 500 ms post-shock onset. Source current density estimations located this activity within the dorsolateral prefrontal cortex (DLPFC, bilaterally), however, only right DLPFC activity...Continue Reading

References

May 1, 1995·Electroencephalography and Clinical Neurophysiology·J Kalcher, G Pfurtscheller
Oct 1, 1994·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·R D Pascual-MarquiD Lehmann
Nov 27, 1999·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·G Pfurtscheller, F H Lopes da Silva
Dec 29, 2000·Neurophysiologie clinique = Clinical neurophysiology·R PeyronL García-Larrea
Apr 11, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A MourauxL Plaghki
Apr 12, 2003·Brain : a Journal of Neurology·J LorenzK L Casey
Jun 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michael D FoxMarcus E Raichle
Jun 28, 2005·European Journal of Pain : EJP·A Vania ApkarianJon-Kar Zubieta
Apr 25, 2006·NeuroImage·Olivier DavidKarl J Friston
Aug 7, 2007·Neuron·Irene Tracey, Patrick W Mantyh
Dec 15, 2007·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Jeffery J BorckardtMark S George
Apr 11, 2008·Annals of the New York Academy of Sciences·Randy L BucknerDaniel L Schacter
Oct 31, 2009·Pain·Peter KrummenacherGeorg Schönbächler
Apr 20, 2010·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·David BorsookLino Becerra
Aug 6, 2010·The Journal of Pain : Official Journal of the American Pain Society·Marina de TommasoPaolo Livrea
Nov 3, 2010·The Journal of Clinical Investigation·Petra Schweinhardt, M Catherine Bushnell
Feb 26, 2011·The Journal of Headache and Pain·Filippo BrighinaBrigida Fierro
Dec 2, 2011·Human Brain Mapping·Emma G Duerden, Marie-Claire Albanese
Apr 28, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Shiyun ShaoXiaoping Li
May 3, 2013·Brain Topography·Philippe GoffauxKevin Whittingstall
May 8, 2013·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Laura MartinMark George

❮ Previous
Next ❯

Citations

Apr 23, 2016·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Iraj Derakhshan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.