Abstract
Background and Purpose- Patients with transient ischemic attack (TIA) occasionally show nonfocal symptoms, such as unconsciousness, amnesia, and unsteadiness. The purpose of this study was to clarify the characteristics and prognosis of patients with TIA with nonfocal symptoms, using data from the PROMISE-TIA (Prospective Multicenter Registry to Identify Subsequent Cardiovascular Events After Transient Ischemic Attack). Methods- Patients with TIA within 7 days of onset were consecutively enrolled in the Japanese nationwide registry. Factors associated with nonfocal symptoms and 1-year risks of ischemic stroke and coronary artery diseases were assessed in multivariate-adjusted models. Results- We studied 1362 patients with TIA (879 men; mean age, 69±12 years), including 219 (16%) with nonfocal symptoms. Patients with TIA with nonfocal symptoms were more likely to show acute ischemic lesions in the posterior circulation on diffusion-weighted imaging (multivariate-adjusted odds ratio, 3.07; 95% confidence interval, 1.57-5.82) and arterial stenosis or occlusion in the posterior circulation on vascular examination (odds ratio, 1.94; 95% confidence interval, 1.19-3.09) than those without nonfocal symptoms. Although 1-year risk of isc...Continue Reading
References
Sep 12, 1992·Lancet·P J KoudstaalJ van Gijn
Sep 12, 2002·Archives of Neurology·Jacob S ElkinsS Claiborne Johnston
Jan 30, 2007·Lancet·S Claiborne JohnstonStephen Sidney
Oct 12, 2007·Lancet Neurology·Philippa C LavalléePierre Amarenco
Nov 13, 2007·Lancet Neurology·Matthew F Giles, Peter M Rothwell
Dec 12, 2007·Archives of Internal Medicine·Caren M WuWilliam A Ghali
Dec 27, 2007·JAMA : the Journal of the American Medical Association·Michiel J BosMonique M B Breteler
May 9, 2009·Stroke; a Journal of Cerebral Circulation·J Donald EastonUNKNOWN Interdisciplinary Council on Peripheral Vascular Disease
Nov 16, 2011·Archives of Neurology·D Eric SearlsLouis R Caplan
Jan 21, 2012·European Neurology·A FörsterK Szabo
Dec 5, 2012·Lancet Neurology·Nicola L M PaulUNKNOWN Oxford Vascular Study
Jun 28, 2013·The New England Journal of Medicine·Yongjun WangUNKNOWN CHANCE Investigators
Jan 10, 2014·Cerebrovascular Diseases Extra·François MoreauShelagh B Coutts
Mar 22, 2014·Stroke; a Journal of Cerebral Circulation·Annette CompterAle Algra
May 3, 2014·Stroke; a Journal of Cerebral Circulation·Walter N KernanUNKNOWN American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and
Oct 9, 2015·Annals of Neurology·Frank G van RooijEwoud J van Dijk
Apr 21, 2016·The New England Journal of Medicine·Pierre AmarencoUNKNOWN TIAregistry.org Investigators
Sep 22, 2016·International Journal of Stroke : Official Journal of the International Stroke Society·Toshiyuki UeharaUNKNOWN PROMISE-TIA study Investigators
Dec 3, 2016·Stroke; a Journal of Cerebral Circulation·Yongjun WangUNKNOWN SOCRATES Steering Committee and Investigators
Jun 7, 2017·Stroke; a Journal of Cerebral Circulation·Takao HoshinoUNKNOWN TIAregistry.org Investigators